3-[hydroxy-(2-pentyl-[1,3]dithian-2-yl)-phenylmethyl]-benzoic acid succinamide ester

Base Information

Chemical Name:3-[hydroxy-(2-pentyl-[1,3]dithian-2-yl)-phenylmethyl]-benzoic acid succinamide ester
CAS No.:918132-30-6
Molecular Formula:C₂₇H₃₁NO₅S₂
Molecular Weight:513.679
Hs Code.:

Synonyms:3-[hydroxy-(2-pentyl-[1,3]dithian-2-yl)-phenylmethyl]-benzoic acid succinamide ester

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Chemical Property of 3-[hydroxy-(2-pentyl-[1,3]dithian-2-yl)-phenylmethyl]-benzoic acid succinamide ester

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Technology Process of 3-[hydroxy-(2-pentyl-[1,3]dithian-2-yl)-phenylmethyl]-benzoic acid succinamide ester

There total 3 articles about 3-[hydroxy-(2-pentyl-[1,3]dithian-2-yl)-phenylmethyl]-benzoic acid succinamide ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 918132-25-9
3-[hydroxy-(2-pentyl-[1,3]dithian-2-yl)-phenylmethyl]-benzoic acid

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 918132-30-6
3-[hydroxy-(2-pentyl-[1,3]dithian-2-yl)-phenylmethyl]-benzoic acid succinamide ester

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1002/anie.200701512

Reference yield:

: 21777-32-2
2-pentyl-1,3-dithiane

: 918132-30-6
3-[hydroxy-(2-pentyl-[1,3]dithian-2-yl)-phenylmethyl]-benzoic acid succinamide ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: butyl lithium / tetrahydrofuran; petroleum ether / 0.17 h / 20 °C

1.2: 70 percent / tetrahydrofuran; petroleum ether / 1.5 h

2.1: 80 percent / 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide HCl / CH₂Cl₂ / 20 °C

With n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; Petroleum ether;
DOI:10.1021/ja066692u

Reference yield:

: 579-18-0
3-benzoylbenzoic acid

: 918132-30-6
3-[hydroxy-(2-pentyl-[1,3]dithian-2-yl)-phenylmethyl]-benzoic acid succinamide ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: butyl lithium / tetrahydrofuran; petroleum ether / 0.17 h / 20 °C

1.2: 70 percent / tetrahydrofuran; petroleum ether / 1.5 h

2.1: 80 percent / 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide HCl / CH₂Cl₂ / 20 °C

With n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; Petroleum ether;
DOI:10.1021/ja066692u