N-((1R,2S)-2-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Base Information

Chemical Name:N-((1R,2S)-2-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea
CAS No.:852660-38-9
Molecular Formula:C₂₆H₃₄FN₇O
Molecular Weight:479.601
Hs Code.:

Synonyms:N-((1R,2S)-2-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

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Chemical Property of N-((1R,2S)-2-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

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Technology Process of N-((1R,2S)-2-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

There total 11 articles about N-((1R,2S)-2-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 852660-41-4
(1R,2S)-2-({[3-(4-fluorophenyl)-propyl]-methyl-amino}-methyl)-cyclohexylamine

: 382637-78-7
[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-carbamic acid phenyl ester

: 852660-38-9
N-((1R,2S)-2-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 15.5h;

Reference yield:

: 7116-38-3
ethyl 3-(4-fluorophenyl)propanoate

: 852660-38-9
N-((1R,2S)-2-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C

1.2: 1 h

2.1: phosphorus tribromide / chloroform / 25 °C / Heating / reflux

3.1: tetrahydrofuran / 25 °C

4.1: potassium carbonate / acetone / 23.5 h / Heating / reflux

5.1: hydrogen / palladium(II) hydroxide/carbon / methanol / 16.5 h / 3604.44 Torr

6.1: triethylamine / acetonitrile / 15.5 h / 20 °C

With lithium aluminium tetrahydride; hydrogen; phosphorus tribromide; potassium carbonate; triethylamine; palladium(II) hydroxide/carbon; In tetrahydrofuran; methanol; chloroform; acetone; acetonitrile;

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 852660-38-9
N-((1R,2S)-2-{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene / Heating / reflux

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2585.81 Torr

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C

3.2: 1 h

4.1: phosphorus tribromide / chloroform / 25 °C / Heating / reflux

5.1: tetrahydrofuran / 25 °C

6.1: potassium carbonate / acetone / 23.5 h / Heating / reflux

7.1: hydrogen / palladium(II) hydroxide/carbon / methanol / 16.5 h / 3604.44 Torr

8.1: triethylamine / acetonitrile / 15.5 h / 20 °C

With lithium aluminium tetrahydride; hydrogen; phosphorus tribromide; potassium carbonate; triethylamine; palladium(II) hydroxide/carbon; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; chloroform; acetone; toluene; acetonitrile;