(1R,2S)-2-({[3-(4-fluorophenyl)-propyl]-methyl-amino}-methyl)-cyclohexylamine

Base Information

Chemical Name:(1R,2S)-2-({[3-(4-fluorophenyl)-propyl]-methyl-amino}-methyl)-cyclohexylamine
CAS No.:852660-41-4
Molecular Formula:C₁₇H₂₇FN₂
Molecular Weight:278.413
Hs Code.:

Synonyms:(1R,2S)-2-({[3-(4-fluorophenyl)-propyl]-methyl-amino}-methyl)-cyclohexylamine

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Chemical Property of (1R,2S)-2-({[3-(4-fluorophenyl)-propyl]-methyl-amino}-methyl)-cyclohexylamine

Chemical Property:

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Technology Process of (1R,2S)-2-({[3-(4-fluorophenyl)-propyl]-methyl-amino}-methyl)-cyclohexylamine

There total 10 articles about (1R,2S)-2-({[3-(4-fluorophenyl)-propyl]-methyl-amino}-methyl)-cyclohexylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 852660-40-3
(1R,2S)-[2-({[3-(4-fluoro-phenyl)-propyl]-methyl-amino}-methyl)-cyclohexyl]-carbamic acid benzyl ester

: 852660-41-4
(1R,2S)-2-({[3-(4-fluorophenyl)-propyl]-methyl-amino}-methyl)-cyclohexylamine

Guidance literature:: With hydrogen; palladium(II) hydroxide/carbon; In methanol; for 16.5h; under 3604.44 Torr;

Reference yield:

: 7116-38-3
ethyl 3-(4-fluorophenyl)propanoate

: 852660-41-4
(1R,2S)-2-({[3-(4-fluorophenyl)-propyl]-methyl-amino}-methyl)-cyclohexylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C

1.2: 1 h

2.1: phosphorus tribromide / chloroform / 25 °C / Heating / reflux

3.1: tetrahydrofuran / 25 °C

4.1: potassium carbonate / acetone / 23.5 h / Heating / reflux

5.1: hydrogen / palladium(II) hydroxide/carbon / methanol / 16.5 h / 3604.44 Torr

With lithium aluminium tetrahydride; hydrogen; phosphorus tribromide; potassium carbonate; palladium(II) hydroxide/carbon; In tetrahydrofuran; methanol; chloroform; acetone;

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 852660-41-4
(1R,2S)-2-({[3-(4-fluorophenyl)-propyl]-methyl-amino}-methyl)-cyclohexylamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / Heating / reflux

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2585.81 Torr

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C

3.2: 1 h

4.1: phosphorus tribromide / chloroform / 25 °C / Heating / reflux

5.1: tetrahydrofuran / 25 °C

6.1: potassium carbonate / acetone / 23.5 h / Heating / reflux

7.1: hydrogen / palladium(II) hydroxide/carbon / methanol / 16.5 h / 3604.44 Torr

With lithium aluminium tetrahydride; hydrogen; phosphorus tribromide; potassium carbonate; palladium(II) hydroxide/carbon; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; chloroform; acetone; toluene;