(S)-(4,5-Bis-benzyloxy-2-fluoro-phenyl)-trimethylsilanyloxy-acetonitrile

Base Information

Chemical Name:(S)-(4,5-Bis-benzyloxy-2-fluoro-phenyl)-trimethylsilanyloxy-acetonitrile
CAS No.:1027922-55-9
Molecular Formula:C₂₅H₂₆FNO₃Si
Molecular Weight:435.57
Hs Code.:

Synonyms:(S)-(4,5-Bis-benzyloxy-2-fluoro-phenyl)-trimethylsilanyloxy-acetonitrile

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Chemical Property of (S)-(4,5-Bis-benzyloxy-2-fluoro-phenyl)-trimethylsilanyloxy-acetonitrile

Chemical Property:

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Technology Process of (S)-(4,5-Bis-benzyloxy-2-fluoro-phenyl)-trimethylsilanyloxy-acetonitrile

There total 1 articles about (S)-(4,5-Bis-benzyloxy-2-fluoro-phenyl)-trimethylsilanyloxy-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: 71924-67-9
4,5-bis(benzyloxy)-2-fluorobenzaldehyde

: (R)-(4,5-Bis-benzyloxy-2-fluoro-phenyl)-trimethylsilanyloxy-acetonitrile

: 1027922-55-9
(S)-(4,5-Bis-benzyloxy-2-fluoro-phenyl)-trimethylsilanyloxy-acetonitrile

Guidance literature:: With (R,R)-salen*Ti(O-i-Pr)4; In dichloromethane; at -50 ℃; for 120h; Title compound not separated from byproducts.;
DOI:10.1021/jm990599h

Reference yield:

: 1027922-55-9
(S)-(4,5-Bis-benzyloxy-2-fluoro-phenyl)-trimethylsilanyloxy-acetonitrile

: 269742-60-1
(1S)-2-amino-1-[4,5-bis(benzyloxy)-2-fluorophenyl]ethanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 3h;
DOI:10.1021/jm990599h

Reference yield:

: 1027922-55-9
(S)-(4,5-Bis-benzyloxy-2-fluoro-phenyl)-trimethylsilanyloxy-acetonitrile

: (S)-6-fluoronorepinephrine hydrogen oxalate

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether / 3 h / 20 °C

2: 87 percent / H₂ / 10percent Pd/C / methanol / 24 h / 2327.23 Torr

With lithium aluminium tetrahydride; hydrogen; 10percent Pd/C; In methanol; diethyl ether; 1: Reduction / 2: Catalytic hydrogenation;
DOI:10.1021/jm990599h