methyl 17ζ-hydroxy-12-methoxy-4α,17ζ-dimethyl-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15-tetraene-4β-carboxylate

Base Information

• Chemical Name: methyl 17ζ-hydroxy-12-methoxy-4α,17ζ-dimethyl-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15-tetraene-4β-carboxylate
• CAS No.: 128344-67-2
• Molecular Formula: C₃₅H₃₈O₄
• Molecular Weight: 522.684
• Mol file: 128344-67-2.mol

Synonyms:methyl 17ζ-hydroxy-12-methoxy-4α,17ζ-dimethyl-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15-tetraene-4β-carboxylate

Chemical Property of methyl 17ζ-hydroxy-12-methoxy-4α,17ζ-dimethyl-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15-tetraene-4β-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 17ζ-hydroxy-12-methoxy-4α,17ζ-dimethyl-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15-tetraene-4β-carboxylate

There total 2 articles about methyl 17ζ-hydroxy-12-methoxy-4α,17ζ-dimethyl-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15-tetraene-4β-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diphenyl acetylene (501-65-5) → methyl 17ζ-hydroxy-12-methoxy-4α,17ζ-dimethyl-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15-tetraene-4β-carboxylate (128344-67-2)

Guidance literature:

With trimethylamine-N-oxide; Yield given. Multistep reaction; 1.) benzene, RT, 5 min, 2.) benzene, RT, 16 h;

DOI:10.1016/0022-328X(92)83317-B

Reference yield:

methyl 13-acetyl-12-methoxypodocarpa-8,11,13-trien-19-oate (29271-64-5) + diphenyl acetylene (501-65-5) → methyl 17ζ-hydroxy-12-methoxy-4α,17ζ-dimethyl-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15-tetraene-4β-carboxylate (128344-67-2)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1016/0022-328X(90)85462-8

Reference yield: 90.0%

methyl 17ζ-hydroxy-12-methoxy-4α,17ζ-dimethyl-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15-tetraene-4β-carboxylate (128344-67-2) → methyl 12-methoxy-4α-methyl-17-methylene-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15,17-pentaene-4β-carboxylate (142452-60-6)

Guidance literature:

With hydrogenchloride; In methanol; chloroform; for 0.666667h; Ambient temperature;

DOI:10.1016/0022-328X(92)83317-B

upstream raw materials:

methyl 13-acetyl-12-methoxypodocarpa-8,11,13-trien-19-oate

diphenyl acetylene

Downstream raw materials:

methyl 12-methoxy-4α-methyl-17-methylene-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15,17-pentaene-4β-carboxylate