methyl 12-methoxy-4α-methyl-17-methylene-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15,17-pentaene-4β-carboxylate

Base Information

• Chemical Name: methyl 12-methoxy-4α-methyl-17-methylene-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15,17-pentaene-4β-carboxylate
• CAS No.: 142452-60-6
• Molecular Formula: C₃₅H₃₆O₃
• Molecular Weight: 504.669
• Mol file: 142452-60-6.mol

Synonyms:methyl 12-methoxy-4α-methyl-17-methylene-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15,17-pentaene-4β-carboxylate

Chemical Property of methyl 12-methoxy-4α-methyl-17-methylene-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15,17-pentaene-4β-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 12-methoxy-4α-methyl-17-methylene-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15,17-pentaene-4β-carboxylate

There total 2 articles about methyl 12-methoxy-4α-methyl-17-methylene-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15,17-pentaene-4β-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 17ζ-hydroxy-12-methoxy-4α,17ζ-dimethyl-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15-tetraene-4β-carboxylate (128344-67-2) → methyl 12-methoxy-4α-methyl-17-methylene-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15,17-pentaene-4β-carboxylate (142452-60-6)

Guidance literature:

With hydrogenchloride; In methanol; chloroform; for 0.666667h; Ambient temperature;

DOI:10.1016/0022-328X(92)83317-B

Reference yield:

diphenyl acetylene (501-65-5) → methyl 12-methoxy-4α-methyl-17-methylene-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15,17-pentaene-4β-carboxylate (142452-60-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) trimethylamine N-oxide / 1.) benzene, RT, 5 min, 2.) benzene, RT, 16 h

2: 90 percent / aq. HCl / methanol; CHCl₃ / 0.67 h / Ambient temperature

With hydrogenchloride; trimethylamine-N-oxide; In methanol; chloroform;

DOI:10.1016/0022-328X(92)83317-B

upstream raw materials:

methyl 17ζ-hydroxy-12-methoxy-4α,17ζ-dimethyl-15,16-diphenyl-18-nor-5α-androsta-8,11,13,15-tetraene-4β-carboxylate

diphenyl acetylene