(E)-(1S,3S)-3-(tert-Butyl-diphenyl-silanyl)-4-methyl-1-phenyl-hex-4-en-1-ol

Base Information

Chemical Name:(E)-(1S,3S)-3-(tert-Butyl-diphenyl-silanyl)-4-methyl-1-phenyl-hex-4-en-1-ol
CAS No.:203174-51-0
Molecular Formula:C₂₉H₃₆OSi
Molecular Weight:428.69
Hs Code.:

Synonyms:(E)-(1S,3S)-3-(tert-Butyl-diphenyl-silanyl)-4-methyl-1-phenyl-hex-4-en-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-(1S,3S)-3-(tert-Butyl-diphenyl-silanyl)-4-methyl-1-phenyl-hex-4-en-1-ol

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Technology Process of (E)-(1S,3S)-3-(tert-Butyl-diphenyl-silanyl)-4-methyl-1-phenyl-hex-4-en-1-ol

There total 5 articles about (E)-(1S,3S)-3-(tert-Butyl-diphenyl-silanyl)-4-methyl-1-phenyl-hex-4-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.5%

: 203174-49-6
tert-Butyl-((E)-(S)-4-methyl-1-phenyl-3-phenylsulfanyl-hex-4-enyloxy)-diphenyl-silane

: (E)-(1S,3R)-3-(tert-Butyl-diphenyl-silanyl)-4-methyl-1-phenyl-hex-4-en-1-ol

: 203174-51-0
(E)-(1S,3S)-3-(tert-Butyl-diphenyl-silanyl)-4-methyl-1-phenyl-hex-4-en-1-ol

Guidance literature:: With potassium naphthalenide; In tetrahydrofuran; at -78 ℃; for 0.833333h;
DOI:10.1055/s-1998-1599

Reference yield:

: 497-02-9
(E)-2-methyl-2-buten-1-ol

: 203174-51-0
(E)-(1S,3S)-3-(tert-Butyl-diphenyl-silanyl)-4-methyl-1-phenyl-hex-4-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 0.67 h / -70 °C

2: 1.) Na, 2.) n-BuLi / 1.) CH₂Cl₂, EtOH, 0 deg C, 50 min; r.t., 50 min, 2.) hexane, THF

3: imidazole / CH₂Cl₂ / 2 h / Ambient temperature

4: 94.5 percent / potassium naphthalenide / tetrahydrofuran / 0.83 h / -78 °C

With 1H-imidazole; n-butyllithium; potassium naphthalenide; sodium; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-1998-1599

Reference yield:

: 28127-58-4
sec-butyl tiglate

: 203174-51-0
(E)-(1S,3S)-3-(tert-Butyl-diphenyl-silanyl)-4-methyl-1-phenyl-hex-4-en-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / LiAlH₄, AlCl₃ / diethyl ether; tetrahydrofuran / 0.83 h / -5 °C

2: Et₃N / CH₂Cl₂ / 0.67 h / -70 °C

3: 1.) Na, 2.) n-BuLi / 1.) CH₂Cl₂, EtOH, 0 deg C, 50 min; r.t., 50 min, 2.) hexane, THF

4: imidazole / CH₂Cl₂ / 2 h / Ambient temperature

5: 94.5 percent / potassium naphthalenide / tetrahydrofuran / 0.83 h / -78 °C

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; aluminium trichloride; potassium naphthalenide; sodium; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1055/s-1998-1599