Technology Process of (1S,3S,4S,5S)-3-(tert-Butyl-diphenyl-silanyl)-4-methyl-1-phenyl-hexane-1,5-diol
There total 6 articles about (1S,3S,4S,5S)-3-(tert-Butyl-diphenyl-silanyl)-4-methyl-1-phenyl-hexane-1,5-diol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 93 percent / LiAlH4, AlCl3 / diethyl ether; tetrahydrofuran / 0.83 h / -5 °C
2: Et3N / CH2Cl2 / 0.67 h / -70 °C
3: 1.) Na, 2.) n-BuLi / 1.) CH2Cl2, EtOH, 0 deg C, 50 min; r.t., 50 min, 2.) hexane, THF
4: imidazole / CH2Cl2 / 2 h / Ambient temperature
5: 94.5 percent / potassium naphthalenide / tetrahydrofuran / 0.83 h / -78 °C
6: 1.) Et2BH, 2.) 10percent aq. NaOH, 35percent H2O2 / 1.) THF, 0 deg C, 30 min; r.t., 7 d, 2.) r.t., 3 h
With
1H-imidazole; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; aluminium trichloride; Diethylborane; potassium naphthalenide; dihydrogen peroxide; sodium; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1055/s-1998-1599
- Guidance literature:
-
Multi-step reaction with 5 steps
1: Et3N / CH2Cl2 / 0.67 h / -70 °C
2: 1.) Na, 2.) n-BuLi / 1.) CH2Cl2, EtOH, 0 deg C, 50 min; r.t., 50 min, 2.) hexane, THF
3: imidazole / CH2Cl2 / 2 h / Ambient temperature
4: 94.5 percent / potassium naphthalenide / tetrahydrofuran / 0.83 h / -78 °C
5: 1.) Et2BH, 2.) 10percent aq. NaOH, 35percent H2O2 / 1.) THF, 0 deg C, 30 min; r.t., 7 d, 2.) r.t., 3 h
With
1H-imidazole; sodium hydroxide; n-butyllithium; Diethylborane; potassium naphthalenide; dihydrogen peroxide; sodium; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1055/s-1998-1599
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) Na, 2.) n-BuLi / 1.) CH2Cl2, EtOH, 0 deg C, 50 min; r.t., 50 min, 2.) hexane, THF
2: imidazole / CH2Cl2 / 2 h / Ambient temperature
3: 94.5 percent / potassium naphthalenide / tetrahydrofuran / 0.83 h / -78 °C
4: 1.) Et2BH, 2.) 10percent aq. NaOH, 35percent H2O2 / 1.) THF, 0 deg C, 30 min; r.t., 7 d, 2.) r.t., 3 h
With
1H-imidazole; sodium hydroxide; n-butyllithium; Diethylborane; potassium naphthalenide; dihydrogen peroxide; sodium;
In
tetrahydrofuran; dichloromethane;
DOI:10.1055/s-1998-1599