N,N-bis(2-(1,3-dioxoisoindolin-2-yl)ethyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N,N-bis(2-(1,3-dioxoisoindolin-2-yl)ethyl)-4-methylbenzenesulfonamide
• CAS No.: 23538-91-2
• Molecular Formula: C₂₇H₂₃N₃O₆S
• Molecular Weight: 517.562
• Mol file: 23538-91-2.mol

Synonyms:N,N-bis(2-(1,3-dioxoisoindolin-2-yl)ethyl)-4-methylbenzenesulfonamide

Chemical Property of N,N-bis(2-(1,3-dioxoisoindolin-2-yl)ethyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-bis(2-(1,3-dioxoisoindolin-2-yl)ethyl)-4-methylbenzenesulfonamide

There total 7 articles about N,N-bis(2-(1,3-dioxoisoindolin-2-yl)ethyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

phthalimide (136918-14-4,85-41-6) + N,N-bis(2-chloroethyl)-p-toluenesulfonamide (42137-88-2) → N,N-bis(2-(1,3-dioxoisoindolin-2-yl)ethyl)-4-methylbenzenesulfonamide (23538-91-2)

Guidance literature:

phthalimide; With potassium carbonate; In N,N-dimethyl-formamide; for 0.5h;

N,N-bis(2-chloroethyl)-p-toluenesulfonamide; In N,N-dimethyl-formamide;

DOI:10.1039/c5ra12230a

Reference yield: 72.0%

N,N-bis(tosyloxyethyl)-p-toluenesulfonamide (16695-22-0) + potassium phtalimide (1074-82-4) → N,N-bis(2-(1,3-dioxoisoindolin-2-yl)ethyl)-4-methylbenzenesulfonamide (23538-91-2)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; overnight;

DOI:10.1021/jo00016a018

Reference yield: 52.0%

N,N-bis(tosyloxyethyl)-p-toluenesulfonamide (16695-22-0) + potassium phtalimide (1074-82-4) → N,N-bis(2-(1,3-dioxoisoindolin-2-yl)ethyl)-4-methylbenzenesulfonamide (23538-91-2) + Toluene-4-sulfonic acid 2-[[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-(toluene-4-sulfonyl)-amino]-ethyl ester (119194-59-1)

Guidance literature:

In N,N-dimethyl-formamide; at 50 ℃;

DOI:10.1246/cl.1986.369

upstream raw materials:

N,N-bis(tosyloxyethyl)-p-toluenesulfonamide

potassium phtalimide

bis(phthalimidylethyl)amine

p-toluenesulfonyl chloride

Downstream raw materials:

N,N-bis(2-aminoethyl)-4-methyl-benzenesulfonamide

3-azapentane-1,5-diamine

N-(p-Toluolsulfonyl)-bis-(2-guanidino-ethyl)-amin

1,7-bis(diethoxyphosphoryl)-4,16,19,23-tetrakis(p-tolylsulfonyl)-1,4,7,16,19,22-hexaaza-10,13,25,28-tetraoxacyclotriacontane