1,7-bis(diethoxyphosphoryl)-4,13,16-tris(p-tolylsulfonyl)-10,19-dioxa-1,4,7,13,16-pentaazacycloheneicosane

Base Information

• Chemical Name: 1,7-bis(diethoxyphosphoryl)-4,13,16-tris(p-tolylsulfonyl)-10,19-dioxa-1,4,7,13,16-pentaazacycloheneicosane
• CAS No.: 134209-63-5
• Molecular Formula: C₄₃H₆₉N₅O₁₄P₂S₃
• Molecular Weight: 1038.19
• Mol file: 134209-63-5.mol

Synonyms:1,7-bis(diethoxyphosphoryl)-4,13,16-tris(p-tolylsulfonyl)-10,19-dioxa-1,4,7,13,16-pentaazacycloheneicosane

Chemical Property of 1,7-bis(diethoxyphosphoryl)-4,13,16-tris(p-tolylsulfonyl)-10,19-dioxa-1,4,7,13,16-pentaazacycloheneicosane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,7-bis(diethoxyphosphoryl)-4,13,16-tris(p-tolylsulfonyl)-10,19-dioxa-1,4,7,13,16-pentaazacycloheneicosane

There total 4 articles about 1,7-bis(diethoxyphosphoryl)-4,13,16-tris(p-tolylsulfonyl)-10,19-dioxa-1,4,7,13,16-pentaazacycloheneicosane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-bis(2-(1,3-dioxoisoindolin-2-yl)ethyl)-4-methylbenzenesulfonamide (23538-91-2) → 1,7-bis(diethoxyphosphoryl)-4,13,16-tris(p-tolylsulfonyl)-10,19-dioxa-1,4,7,13,16-pentaazacycloheneicosane (134209-63-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / 85percent N₂H₄*H₂O / ethanol / 24 h / Heating

2: 66 percent / K₂CO₃, KHCO₃, (Bu)4NBr / CCl₄; CH₂Cl₂ / overnight, 0 deg C - r.t.

3: NaH / DMSO, 70-80 deg C, 4 h

With tetrabutylammomium bromide; sodium hydride; potassium carbonate; potassium hydrogencarbonate; hydrazine hydrate; In tetrachloromethane; ethanol; dichloromethane;

DOI:10.1021/jo00016a018

Reference yield:

N,N-bis(2-aminoethyl)-4-methyl-benzenesulfonamide (23539-15-3) → 1,7-bis(diethoxyphosphoryl)-4,13,16-tris(p-tolylsulfonyl)-10,19-dioxa-1,4,7,13,16-pentaazacycloheneicosane (134209-63-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / K₂CO₃, KHCO₃, (Bu)4NBr / CCl₄; CH₂Cl₂ / overnight, 0 deg C - r.t.

2: NaH / DMSO, 70-80 deg C, 4 h

With tetrabutylammomium bromide; sodium hydride; potassium carbonate; potassium hydrogencarbonate; In tetrachloromethane; dichloromethane;

DOI:10.1021/jo00016a018

Reference yield:

potassium phtalimide (1074-82-4) → 1,7-bis(diethoxyphosphoryl)-4,13,16-tris(p-tolylsulfonyl)-10,19-dioxa-1,4,7,13,16-pentaazacycloheneicosane (134209-63-5)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine

2: 96 percent / 85percent N₂H₄*H₂O / ethanol / 24 h / Heating

3: 66 percent / K₂CO₃, KHCO₃, (Bu)4NBr / CCl₄; CH₂Cl₂ / overnight, 0 deg C - r.t.

4: NaH / DMSO, 70-80 deg C, 4 h

With pyridine; tetrabutylammomium bromide; sodium hydride; potassium carbonate; potassium hydrogencarbonate; hydrazine hydrate; In tetrachloromethane; ethanol; dichloromethane;

DOI:10.1021/jo00016a018

upstream raw materials:

N,N''-bis(diethoxyphosphoryl)-N'-tosyldiethylenetriamine

6,9-di(p-toluenesulfonyl)-1,14-di(p-toluenesulfonyloxy)-6,9-diazatetradecane

N,N-bis(2-(1,3-dioxoisoindolin-2-yl)ethyl)-4-methylbenzenesulfonamide

N,N-bis(2-aminoethyl)-4-methyl-benzenesulfonamide

Downstream raw materials:

1,4,13-tris(p-tolylsulfonyl)-7,9-dioxa-1,4,10,13,16-pentaazacycloheneicosane dihydrochloride