(3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone

Base Information

Chemical Name:(3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone
CAS No.:91841-40-6
Molecular Formula:C₁₈H₂₈N₂O₄Si
Molecular Weight:364.517
Hs Code.:

Synonyms:(3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone

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Technology Process of (3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone

There total 4 articles about (3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 91841-39-3
(3S,4R)-1-tert-butyldimethylsilyl-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone

: 91841-40-6
(3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone

Guidance literature:: With potassium fluoride; acetic acid; In methanol; at 0 ℃; for 15h;
DOI:10.1248/cpb.32.1303

Reference yield:

: 91814-60-7
(4R)-1-tert-butyldimethylsilyl-3-tert-butyldimethylsilyloxymethyl-2-azetidinone

: 91841-40-6
(3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone

Guidance literature:: Multi-step reaction with 4 steps

2: H₂ / 10 percent Pd-C / tetrahydrofuran / 1.5 h / Ambient temperature

3: N,N'-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / tetrahydrofuran / 2 h / Ambient temperature

4: 99 percent / 1) potassium fluoride; 2) acetic acid / methanol / 15 h / 0 °C

With potassium fluoride; hydrogen; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1248/cpb.32.1303

Reference yield:

: 91841-31-5
(3S,4R)-3-azido-1-tert-butyldimethylsilyl-4-tert-butyldimethylsilyloxymethyl-2-azetidinone

: 91841-40-6
(3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10 percent Pd-C / tetrahydrofuran / 1.5 h / Ambient temperature

2: N,N'-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / tetrahydrofuran / 2 h / Ambient temperature

3: 99 percent / 1) potassium fluoride; 2) acetic acid / methanol / 15 h / 0 °C

With potassium fluoride; hydrogen; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1248/cpb.32.1303