(3S,4R)-1-tert-butyldimethylsilyl-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone

Base Information

Chemical Name:(3S,4R)-1-tert-butyldimethylsilyl-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone
CAS No.:91841-39-3
Molecular Formula:C₂₄H₄₂N₂O₄Si₂
Molecular Weight:478.779
Hs Code.:

Synonyms:(3S,4R)-1-tert-butyldimethylsilyl-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone

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Chemical Property of (3S,4R)-1-tert-butyldimethylsilyl-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone

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Technology Process of (3S,4R)-1-tert-butyldimethylsilyl-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone

There total 3 articles about (3S,4R)-1-tert-butyldimethylsilyl-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 91814-60-7
(4R)-1-tert-butyldimethylsilyl-3-tert-butyldimethylsilyloxymethyl-2-azetidinone

: 91841-39-3
(3S,4R)-1-tert-butyldimethylsilyl-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone

Guidance literature:: Multi-step reaction with 3 steps

2: H₂ / 10 percent Pd-C / tetrahydrofuran / 1.5 h / Ambient temperature

3: N,N'-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / tetrahydrofuran / 2 h / Ambient temperature

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1248/cpb.32.1303

Reference yield:

: 91841-31-5
(3S,4R)-3-azido-1-tert-butyldimethylsilyl-4-tert-butyldimethylsilyloxymethyl-2-azetidinone

: 91841-39-3
(3S,4R)-1-tert-butyldimethylsilyl-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10 percent Pd-C / tetrahydrofuran / 1.5 h / Ambient temperature

2: N,N'-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / tetrahydrofuran / 2 h / Ambient temperature

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1248/cpb.32.1303

Reference yield:

: 98833-26-2,98857-44-4
(3S,4R)-3-Amino-1-(tert-butyl-dimethyl-silanyl)-4-(tert-butyl-dimethyl-silanyloxymethyl)-azetidin-2-one

: 122-59-8
2-phenoxyacetic acid

: 91841-39-3
(3S,4R)-1-tert-butyldimethylsilyl-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; for 2h; Yield given; Ambient temperature;
DOI:10.1248/cpb.32.1303