tetrahydrofuran-2-ylmethyl 2'-(aminomethyl)-5'-{[(3-fluoropyridin-4-yl)amino]carbonyl} biphenyl-3-carboxylate

Base Information

Chemical Name:tetrahydrofuran-2-ylmethyl 2'-(aminomethyl)-5'-{[(3-fluoropyridin-4-yl)amino]carbonyl} biphenyl-3-carboxylate
CAS No.:1333400-46-6
Molecular Formula:C₂₅H₂₄FN₃O₄
Molecular Weight:449.482
Hs Code.:

Synonyms:tetrahydrofuran-2-ylmethyl 2'-(aminomethyl)-5'-{[(3-fluoropyridin-4-yl)amino]carbonyl} biphenyl-3-carboxylate

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Chemical Property of tetrahydrofuran-2-ylmethyl 2'-(aminomethyl)-5'-{[(3-fluoropyridin-4-yl)amino]carbonyl} biphenyl-3-carboxylate

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Technology Process of tetrahydrofuran-2-ylmethyl 2'-(aminomethyl)-5'-{[(3-fluoropyridin-4-yl)amino]carbonyl} biphenyl-3-carboxylate

There total 10 articles about tetrahydrofuran-2-ylmethyl 2'-(aminomethyl)-5'-{[(3-fluoropyridin-4-yl)amino]carbonyl} biphenyl-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₂FN₃O₆

: 1333400-46-6
tetrahydrofuran-2-ylmethyl 2'-(aminomethyl)-5'-{[(3-fluoropyridin-4-yl)amino]carbonyl} biphenyl-3-carboxylate

Guidance literature:: In dichloromethane; at 30 ℃; for 16h; Acidic conditions;
DOI:10.1016/j.bmcl.2013.09.040

Reference yield:

: 2247-88-3
3-fluoro-pyridin-4-ylamine

: 1333400-46-6
tetrahydrofuran-2-ylmethyl 2'-(aminomethyl)-5'-{[(3-fluoropyridin-4-yl)amino]carbonyl} biphenyl-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl acetamide / 16 h / 30 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / N,N-dimethyl-formamide; water / 16 h / 100 °C / Inert atmosphere

3.1: trialkylamine

3.2: 20 °C

4.1: dichloromethane / 16 h / 30 °C / Acidic conditions

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; 2.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.09.040

Reference yield:

: 1333400-88-6
[2-bromo-4-{3-fluoro-pyridin-4-ylcarbamoyl}-benzyl]-carbamic acid tert butyl ester

: 1333400-46-6
tetrahydrofuran-2-ylmethyl 2'-(aminomethyl)-5'-{[(3-fluoropyridin-4-yl)amino]carbonyl} biphenyl-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / N,N-dimethyl-formamide; water / 16 h / 100 °C / Inert atmosphere

2.1: trialkylamine

2.2: 20 °C

3.1: dichloromethane / 16 h / 30 °C / Acidic conditions

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.09.040