methyl 5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

Base Information

• Chemical Name: methyl 5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate
• CAS No.: 866625-02-7
• Molecular Formula: C₁₄H₁₈BClO₄
• Molecular Weight: 296.559
• Mol file: 866625-02-7.mol

Synonyms:5-chloro-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzoic acid methyl ester

Chemical Property of methyl 5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate ≥97.0% ^*data from reagent suppliers

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Technology Process of methyl 5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

There total 1 articles about methyl 5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl-2-bromo-5-chlorobenzoate (27007-53-0) + bis(pinacol)diborane (73183-34-3) → 5-chloro-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzoic acid methyl ester (866625-02-7)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at -10 - 90 ℃;

Reference yield: 51.0%

potassium hydrogen difluoride + 5-chloro-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzoic acid methyl ester (866625-02-7) → potassium (4-chloro-2-(methoxycarbonyl)phenyl)trifluoroborate

Guidance literature:

In methanol; at 20 ℃; for 0.5h;

DOI:10.1039/c5ob00078e

Reference yield: 48.0%

5-chloro-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzoic acid methyl ester (866625-02-7) + 2-bromo-5-fluoro-4-iodopyridine (1061357-89-8) → methyl 2-(2-bromo-5-fluoropyridin-4-yl)-5-chlorobenzoate

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; at 90 ℃; Inert atmosphere;

upstream raw materials:

methyl-2-bromo-5-chlorobenzoate

bis(pinacol)diborane

Downstream raw materials:

2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid

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