5-(3,4-dimethoxybenzyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline

Base Information

Chemical Name:5-(3,4-dimethoxybenzyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline
CAS No.:5544-50-3
Molecular Formula:C₂₀H₂₃NO₄
Molecular Weight:341.407
Hs Code.:

Synonyms:5-(3,4-dimethoxybenzyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline

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Chemical Property of 5-(3,4-dimethoxybenzyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline

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Technology Process of 5-(3,4-dimethoxybenzyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline

There total 8 articles about 5-(3,4-dimethoxybenzyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 19918-74-2
5-[(3,4-dimethoxyphenyl)methyl]-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline

: 74-88-4
methyl iodide

: 5544-50-3
5-(3,4-dimethoxybenzyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline

Guidance literature:: In acetonitrile; Reflux; Inert atmosphere;
DOI:10.1016/j.bmc.2018.10.020

Reference yield: 53.0%

: 1-(3',4'-dimethoxyphenyl)-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline-methanone-1,2-propylenedithioacetal

: 5544-50-3
5-(3,4-dimethoxybenzyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline

Guidance literature:: With sodium hydroxide; Raney Ni W-2; In tetrahydrofuran; for 5h; Heating;

Reference yield:

: 135798-21-9
C₁₁H₁₃BF₃NO₂

: 5544-50-3
5-(3,4-dimethoxybenzyl)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C

1.2: 3 h / -78 - 25 °C

2.1: methanol / 8 h / Reflux

With lithium aluminium tetrahydride; In tetrahydrofuran; methanol;
DOI:10.1055/s-0036-1588920