N,1-dimethyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-carbohydrazide

Base Information

Chemical Name:N,1-dimethyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-carbohydrazide
CAS No.:1402232-45-4
Molecular Formula:C₁₅H₁₇F₃N₄O
Molecular Weight:326.321
Hs Code.:

Synonyms:N,1-dimethyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-carbohydrazide

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Chemical Property of N,1-dimethyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-carbohydrazide

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Technology Process of N,1-dimethyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-carbohydrazide

There total 5 articles about N,1-dimethyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1359029-69-8
1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-carboxylic acid

: 60-34-4
methylhydrazine

: 1402232-45-4
N,1-dimethyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-carbohydrazide

Guidance literature:: 1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-carboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 0.5h;

methylhydrazine; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 1356997-87-9
4-iodo-1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

: 1402232-45-4
N,1-dimethyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-carbohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 65 °C

2.1: potassium hydroxide; ethanol / 3 h / Reflux

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 °C

3.2: 16 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; potassium carbonate; 1,1'-carbonyldiimidazole; potassium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1356997-45-9
1-methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}-1H-pyrazole

: 1402232-45-4
N,1-dimethyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-carbohydrazide

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

2.1: N-iodo-succinimide; trifluoroacetic acid / 1 h / 20 °C

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 65 °C

4.1: potassium hydroxide; ethanol / 3 h / Reflux

5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 °C

5.2: 16 h / 20 °C

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; palladium 10% on activated carbon; hydrogen; potassium carbonate; 1,1'-carbonyldiimidazole; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;