(R)-2-((3-(((4-(1-adamantyl)benzoyl)amino)methyl)-4-propoxyphenyl)methyl)-4-phenylbutanoic acid

Base Information

Chemical Name:(R)-2-((3-(((4-(1-adamantyl)benzoyl)amino)methyl)-4-propoxyphenyl)methyl)-4-phenylbutanoic acid
CAS No.:1361403-98-6
Molecular Formula:C₃₈H₄₅NO₄
Molecular Weight:579.78
Hs Code.:

Synonyms:(R)-2-((3-(((4-(1-adamantyl)benzoyl)amino)methyl)-4-propoxyphenyl)methyl)-4-phenylbutanoic acid

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Chemical Property of (R)-2-((3-(((4-(1-adamantyl)benzoyl)amino)methyl)-4-propoxyphenyl)methyl)-4-phenylbutanoic acid

Chemical Property:

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Technology Process of (R)-2-((3-(((4-(1-adamantyl)benzoyl)amino)methyl)-4-propoxyphenyl)methyl)-4-phenylbutanoic acid

There total 10 articles about (R)-2-((3-(((4-(1-adamantyl)benzoyl)amino)methyl)-4-propoxyphenyl)methyl)-4-phenylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401791-65-8
4-(1-adamantyl)-N-((5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxyphenyl)methyl)benzamide

: 1361403-98-6
(R)-2-((3-(((4-(1-adamantyl)benzoyl)amino)methyl)-4-propoxyphenyl)methyl)-4-phenylbutanoic acid

Guidance literature:: With lithium hydroxide monohydrate; dihydrogen peroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 5.5h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.08.061

Reference yield:

: 1259391-04-2
benzyl 2-propoxy-5-formylsalicylate

: 1361403-98-6
(R)-2-((3-(((4-(1-adamantyl)benzoyl)amino)methyl)-4-propoxyphenyl)methyl)-4-phenylbutanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: sodium tetrahydroborate / ethanol / 0 - 20 °C

2: phosphorus tribromide / diethyl ether / 2 h / 0 °C

3: sodium hexamethyldisilazane / tetrahydrofuran / -50 - -15 °C / Inert atmosphere

4: 10% Pd/C; hydrogen / ethyl acetate / 1500.15 - 2250.23 Torr

5: borane-THF / 0 - 20 °C

6: pyridinium dichromate / dichloromethane / 12 h / 20 °C

7: triethylsilane; trifluoroacetic acid / toluene / 48 h / Reflux; Inert atmosphere

8: dihydrogen peroxide; lithium hydroxide monohydrate / tetrahydrofuran; water / 5.5 h / 0 - 20 °C / Inert atmosphere

With triethylsilane; sodium tetrahydroborate; borane-THF; lithium hydroxide monohydrate; 10% Pd/C; pyridinium dichromate; hydrogen; dihydrogen peroxide; sodium hexamethyldisilazane; phosphorus tribromide; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1016/j.bmc.2012.08.061

Reference yield:

: 1259391-05-3
benzyl 5-hydroxymethyl-2-propoxybenzoate

: 1361403-98-6
(R)-2-((3-(((4-(1-adamantyl)benzoyl)amino)methyl)-4-propoxyphenyl)methyl)-4-phenylbutanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: phosphorus tribromide / diethyl ether / 2 h / 0 °C

2: sodium hexamethyldisilazane / tetrahydrofuran / -50 - -15 °C / Inert atmosphere

3: 10% Pd/C; hydrogen / ethyl acetate / 1500.15 - 2250.23 Torr

4: borane-THF / 0 - 20 °C

5: pyridinium dichromate / dichloromethane / 12 h / 20 °C

6: triethylsilane; trifluoroacetic acid / toluene / 48 h / Reflux; Inert atmosphere

7: dihydrogen peroxide; lithium hydroxide monohydrate / tetrahydrofuran; water / 5.5 h / 0 - 20 °C / Inert atmosphere

With triethylsilane; borane-THF; lithium hydroxide monohydrate; 10% Pd/C; pyridinium dichromate; hydrogen; dihydrogen peroxide; sodium hexamethyldisilazane; phosphorus tribromide; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1016/j.bmc.2012.08.061