benzyl 5-hydroxymethyl-2-propoxybenzoate

Base Information

• Chemical Name: benzyl 5-hydroxymethyl-2-propoxybenzoate
• CAS No.: 1259391-05-3
• Molecular Formula: C₁₈H₂₀O₄
• Molecular Weight: 300.354
• Mol file: 1259391-05-3.mol

Synonyms:benzyl 5-hydroxymethyl-2-propoxybenzoate

Chemical Property of benzyl 5-hydroxymethyl-2-propoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 5-hydroxymethyl-2-propoxybenzoate

There total 4 articles about benzyl 5-hydroxymethyl-2-propoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzyl 2-propoxy-5-formylsalicylate (1259391-04-2) → benzyl 5-hydroxymethyl-2-propoxybenzoate (1259391-05-3)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2012.08.061

Reference yield:

2-hydroxy-5-formylbenzoic acid (616-76-2) → benzyl 5-hydroxymethyl-2-propoxybenzoate (1259391-05-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 24 h / 60 °C

3: sodium tetrahydroborate / ethanol / 0 - 20 °C

With sodium tetrahydroborate; potassium carbonate; potassium hydrogencarbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm101233f

Reference yield:

benzyl bromide (100-39-0) → benzyl 5-hydroxymethyl-2-propoxybenzoate (1259391-05-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 24 h / 60 °C

3: sodium tetrahydroborate / ethanol / 0 - 20 °C

With sodium tetrahydroborate; potassium carbonate; potassium hydrogencarbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm101233f

upstream raw materials:

benzyl 2-propoxy-5-formylsalicylate

2-hydroxy-5-formylbenzoic acid

benzyl bromide

benzyl 2-hydroxy-5-formylbenzoate

Downstream raw materials:

benzyl 5-bromomethyl-2-propoxybenzoate

benzyl 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoate

5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoic acid

5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxy-benzaldehyde