H-Val-OBu^t*TosOH

Base Information

• Chemical Name: H-Val-OBu^t*TosOH
• CAS No.: 97268-33-2
• Molecular Formula: C₇H₈O₃S*C₉H₁₉NO₂
• Molecular Weight: 345.46
• Mol file: 97268-33-2.mol

Synonyms:H-Val-OBu^t*TosOH

Chemical Property of H-Val-OBu^t*TosOH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H-Val-OBu^t*TosOH

There total 1 articles about H-Val-OBu^t*TosOH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

benzyl (S)-1-(tert-butoxycarbonyl)-2-methylpropylcarbamate (16874-02-5) + toluene-4-sulfonic acid (104-15-4) → H-Val-OBut*TosOH (97268-33-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 8h;

DOI:10.1002/jlac.198619860507

Reference yield: 93.0%

Ddz-Glu(OBzl)-OH (51219-79-5) + H-Val-OBut*TosOH (97268-33-2) → Ddz-Glu(OBzl)-Val-OBut (97251-07-5)

Guidance literature:

With 4-methyl-morpholine; In dichloromethane; 1.) -15 deg C to room temp., 2.) 2d, room temp.;

DOI:10.1002/jlac.198619860507

Reference yield: 88.0%

Ddz-Asp(OBzl)-OH (70082-73-4) + H-Val-OBut*TosOH (97268-33-2) → Ddz-Asp(OBzl)-Val-OBut (97251-02-0)

Guidance literature:

With 4-methyl-morpholine; In dichloromethane; 1.) -15 deg C to room temp., 2.) 2d, room temp.;

DOI:10.1002/jlac.198619860507

upstream raw materials:

benzyl (S)-1-(tert-butoxycarbonyl)-2-methylpropylcarbamate

toluene-4-sulfonic acid

Downstream raw materials:

Ddz-Asp(OBzl)-Val-OBu^t

Ddz-Glu(OBzl)-Val-OBu^t

H-Asp(OBzl)-Val-OBu^t*TFA

cyclo<-Tyr-Arg(NO2)-D-Lys(Z)-Asp(OBzl)-D-Val->

Refernces