10.1016/j.tetlet.2011.09.093
The study presents an efficient and selective method for synthesizing hybrid trifluoromethyl-substituted γ-lactones and fused nitrogen heterocycles through cascade reactions. The chemicals used include pyridazine derivatives, which exhibit a range of biological effects such as antiviral, anticancer, and antibacterial properties, and fluorine-containing compounds that are significant in the development of anti-HIV, antiviral, anticancer, antibacterial, and antifungal medicines. The purpose of these chemicals is to combine their biological potentials by synthesizing a hybrid pyridazine-fluorine moiety. The reaction pathway involves the use of diazinium ylides, which react with 2-(trifluoromethyl) acrylic acid to produce a new class of γ-lactones with nitrogen heterocyclic skeletons, demonstrating both stereoselectivity and stereospecificity depending on the nitrogen heterocycle used. The study also explores the reaction mechanisms and structures of the resulting compounds, providing a novel route for obtaining hybrid fluorine-nitrogen heterocycles with potential applications in medicinal chemistry.
10.3987/COM-03-9960
The study investigates the synthesis and transformations of 3-diazopyrazolo[3,4-c]pyridazine, a heterocyclic diazo compound. It reacts with various reactive methylene compounds, such as ethyl cyanoacetate, diethyl malonate, and cyclohexane-1,3-dione, to form corresponding hydrazones and condensed 1,2,4-triazines. The diazo compound also undergoes azo coupling with aromatic amines and naphthols to produce arylazo derivatives. Additionally, it participates in cycloaddition reactions with dipolarophiles like phenyl isothiocyanate and dimethyl acetylenedicarboxylate, yielding cycloaddition products. The study explores the synthetic potential of fused pyridazine systems and highlights the diverse reactivity of the diazo compound, with products characterized by spectroscopic methods.
