ethyl 5-methyl-2-[4-(trifluoromethyl)phenyl]-1,2,3-triazole-4-carboxylate

Base Information

Chemical Name:ethyl 5-methyl-2-[4-(trifluoromethyl)phenyl]-1,2,3-triazole-4-carboxylate
CAS No.:870788-48-0
Molecular Formula:C₁₃H₁₂F₃N₃O₂
Molecular Weight:299.252
Hs Code.:

Synonyms:ethyl 5-methyl-2-[4-(trifluoromethyl)phenyl]-1,2,3-triazole-4-carboxylate

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Chemical Property of ethyl 5-methyl-2-[4-(trifluoromethyl)phenyl]-1,2,3-triazole-4-carboxylate

Chemical Property:

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Technology Process of ethyl 5-methyl-2-[4-(trifluoromethyl)phenyl]-1,2,3-triazole-4-carboxylate

There total 2 articles about ethyl 5-methyl-2-[4-(trifluoromethyl)phenyl]-1,2,3-triazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.7%

: 455-14-1
4-trifluoromethylphenylamine

: 141-97-9
ethyl acetoacetate

: 870788-48-0
ethyl 5-methyl-2-[4-(trifluoromethyl)phenyl]-1,2,3-triazole-4-carboxylate

Guidance literature:: 4-trifluoromethylphenylamine; With hydrogenchloride; sodium nitrite; In water; acetic acid; at 0 ℃;

ethyl acetoacetate; With sodium acetate; sodium carbonate; In ethanol; water; acetic acid; at 0 - 20 ℃; for 2h;

With copper(II) choride dihydrate; ammonium acetate; In ethanol; for 20h; Reflux;
DOI:10.1021/acs.jmedchem.1c00560

Reference yield:

: 90774-69-9
4-aminobenzotrifluoride hydrochloride

: 141-97-9
ethyl acetoacetate

: 870788-48-0
ethyl 5-methyl-2-[4-(trifluoromethyl)phenyl]-1,2,3-triazole-4-carboxylate

Guidance literature:: 4-aminobenzotrifluoride hydrochloride; With hydrogenchloride; sodium nitrite; In water; acetic acid; at 5 ℃;

ethyl acetoacetate; With sodium acetate; sodium carbonate; In ethanol; water; acetic acid; at 0 ℃; for 2h;

With ammonium acetate; copper dichloride; In ethanol; for 12h; Heating / reflux;