2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-dihydroxyphenyl)propyl]amide

Base Information

Chemical Name:2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-dihydroxyphenyl)propyl]amide
CAS No.:1370339-87-9
Molecular Formula:C₃₁H₃₂ClN₇O₃
Molecular Weight:586.093
Hs Code.:

Synonyms:2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-dihydroxyphenyl)propyl]amide

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Chemical Property of 2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-dihydroxyphenyl)propyl]amide

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Technology Process of 2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-dihydroxyphenyl)propyl]amide

There total 5 articles about 2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-dihydroxyphenyl)propyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1370339-86-8
2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-bis-benzyloxyphenyl)propyl]amide

: 1370339-87-9
2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-dihydroxyphenyl)propyl]amide

Guidance literature:: With 30% Pd/C; hydrogen; In methanol; at 20 ℃; for 1h; under 760.051 Torr;
DOI:10.1016/j.ejmech.2012.01.043

Reference yield:

: 1375180-02-1
benzyl 3-(3,4-bis(benzyloxy)phenyl)propanoate

: 1370339-87-9
2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-dihydroxyphenyl)propyl]amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2.5 h / 0 - 20 °C

1.2: pH 1

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

3.1: hydrazine hydrate / ethanol / 10 h / Reflux

4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 h / 60 °C / Inert atmosphere

4.2: 4 h / 60 °C / Inert atmosphere

5.1: 30% Pd/C; hydrogen / methanol / 1 h / 20 °C / 760.05 Torr

With lithium aluminium tetrahydride; 30% Pd/C; hydrogen; hydrazine hydrate; triphenylphosphine; 1,1'-carbonyldiimidazole; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether; ethanol;
DOI:10.1016/j.ejmech.2012.01.043

Reference yield:

: 1078-61-1
dihydrocaffeic acid

: 1370339-87-9
2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-dihydroxyphenyl)propyl]amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 60 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2.5 h / 0 - 20 °C

2.2: pH 1

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

4.1: hydrazine hydrate / ethanol / 10 h / Reflux

5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 h / 60 °C / Inert atmosphere

5.2: 4 h / 60 °C / Inert atmosphere

6.1: 30% Pd/C; hydrogen / methanol / 1 h / 20 °C / 760.05 Torr

With lithium aluminium tetrahydride; 30% Pd/C; hydrogen; potassium carbonate; hydrazine hydrate; triphenylphosphine; 1,1'-carbonyldiimidazole; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.043