2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-bis-benzyloxyphenyl)propyl]amide

Base Information

• Chemical Name: 2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-bis-benzyloxyphenyl)propyl]amide
• CAS No.: 1370339-86-8
• Molecular Formula: C₄₅H₄₄ClN₇O₃
• Molecular Weight: 766.342
• Mol file: 1370339-86-8.mol

Synonyms:2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-bis-benzyloxyphenyl)propyl]amide

Chemical Property of 2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-bis-benzyloxyphenyl)propyl]amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-bis-benzyloxyphenyl)propyl]amide

There total 6 articles about 2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-bis-benzyloxyphenyl)propyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid (124750-92-1) + 3-<3,4-bis(benzyloxy)phenyl>-1-aminopropane (99281-96-6) → 2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-bis-benzyloxyphenyl)propyl]amide (1370339-86-8)

Guidance literature:

2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 60 ℃; for 20h; Inert atmosphere;

3-<3,4-bis(benzyloxy)phenyl>-1-aminopropane; In tetrahydrofuran; at 60 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.ejmech.2012.01.043

Reference yield:

benzyl 3-(3,4-bis(benzyloxy)phenyl)propanoate (1375180-02-1) → 2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-bis-benzyloxyphenyl)propyl]amide (1370339-86-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2.5 h / 0 - 20 °C

1.2: pH 1

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

3.1: hydrazine hydrate / ethanol / 10 h / Reflux

4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 h / 60 °C / Inert atmosphere

4.2: 4 h / 60 °C / Inert atmosphere

With lithium aluminium tetrahydride; hydrazine hydrate; triphenylphosphine; 1,1'-carbonyldiimidazole; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; ethanol;

DOI:10.1016/j.ejmech.2012.01.043

Reference yield:

dihydrocaffeic acid (1078-61-1) → 2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-bis-benzyloxyphenyl)propyl]amide (1370339-86-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 60 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2.5 h / 0 - 20 °C

2.2: pH 1

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

4.1: hydrazine hydrate / ethanol / 10 h / Reflux

5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 h / 60 °C / Inert atmosphere

5.2: 4 h / 60 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; hydrazine hydrate; triphenylphosphine; 1,1'-carbonyldiimidazole; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2012.01.043

upstream raw materials:

benzyl 3-(3,4-bis(benzyloxy)phenyl)propanoate

2-[3-(3,4-bis-benzyloxy-phenyl)propyl]isoindole-1,3-dione

3-[3,4-bis(benzyloxy)phenyl]propan-1-ol

dihydrocaffeic acid

Downstream raw materials:

2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid[3-(3,4-dihydroxyphenyl)propyl]amide