2-[2-(2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-decanoylamino]-decanoic acid methyl ester; hydrochloride

Base Information

Chemical Name:2-[2-(2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-decanoylamino]-decanoic acid methyl ester; hydrochloride
CAS No.:129851-14-5
Molecular Formula:C₃₅H₆₀N₄O₆*ClH
Molecular Weight:669.346
Hs Code.:

Synonyms:2-[2-(2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-decanoylamino]-decanoic acid methyl ester; hydrochloride

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Chemical Property of 2-[2-(2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-decanoylamino]-decanoic acid methyl ester; hydrochloride

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Technology Process of 2-[2-(2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-decanoylamino]-decanoic acid methyl ester; hydrochloride

There total 8 articles about 2-[2-(2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-decanoylamino]-decanoic acid methyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 129851-11-2
2-[2-(6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-decanoylamino]-decanoic acid methyl ester

: 129851-14-5
2-[2-(2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-decanoylamino]-decanoic acid methyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; Heating;

Reference yield:

: 17702-88-4
rac-2-aminodecanoic acid

: 129851-14-5
2-[2-(2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-decanoylamino]-decanoic acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / thionyl chloride / 24 h / Heating

2: 92 percent / triethylamine, 3-<3-(dimethylamino)propyl>-1-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole hydrate, tributylicosanoylammonium sulphate / CH₂Cl₂ / 1) 0 deg C, 1 h; 2) 20 deg C, ca. 12 h

3: 99 percent / 3 percent HCl / methanol / 0.42 h / Heating

4: 96 percent / triethylamine, 3-<3-(dimethylamino)propyl>-1-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole hydrate, tributylicosanoylammonium sulphate / CH₂Cl₂ / 1) 0 deg C; 2) 20 deg C

5: 90 percent / 3 percent HCl / methanol / Heating

With hydrogenchloride; thionyl chloride; tributylcosanoyl ammonium sulphate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;

Reference yield:

: 111-83-1
1-bromo-octane

: 129851-14-5
2-[2-(2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-decanoylamino]-decanoic acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: NaOEt / 24 h / Heating

2: HCl / dimethylformamide / 24 h / Heating

3: 91 percent / thionyl chloride / 24 h / Heating

4: 92 percent / triethylamine, 3-<3-(dimethylamino)propyl>-1-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole hydrate, tributylicosanoylammonium sulphate / CH₂Cl₂ / 1) 0 deg C, 1 h; 2) 20 deg C, ca. 12 h

5: 99 percent / 3 percent HCl / methanol / 0.42 h / Heating

6: 96 percent / triethylamine, 3-<3-(dimethylamino)propyl>-1-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole hydrate, tributylicosanoylammonium sulphate / CH₂Cl₂ / 1) 0 deg C; 2) 20 deg C

7: 90 percent / 3 percent HCl / methanol / Heating

With hydrogenchloride; thionyl chloride; tributylcosanoyl ammonium sulphate; sodium ethanolate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;