2-[2-(6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-decanoylamino]-decanoic acid methyl ester

Base Information

Chemical Name:2-[2-(6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-decanoylamino]-decanoic acid methyl ester
CAS No.:129851-11-2
Molecular Formula:C₄₀H₆₈N₄O₈
Molecular Weight:733.002
Hs Code.:

Synonyms:2-[2-(6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-decanoylamino]-decanoic acid methyl ester

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Chemical Property of 2-[2-(6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-decanoylamino]-decanoic acid methyl ester

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Technology Process of 2-[2-(6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-decanoylamino]-decanoic acid methyl ester

There total 7 articles about 2-[2-(6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-decanoylamino]-decanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 2389-45-9
Boc-Lys(Z)-OH

: 129850-68-6
α-hydro-ω-methoxybis hydrochloride

: 129851-11-2
2-[2-(6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-decanoylamino]-decanoic acid methyl ester

Guidance literature:: With tributylcosanoyl ammonium sulphate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; 1) 0 deg C; 2) 20 deg C;

Reference yield:

: 17702-88-4
rac-2-aminodecanoic acid

: 129851-11-2
2-[2-(6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-decanoylamino]-decanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / thionyl chloride / 24 h / Heating

2: 92 percent / triethylamine, 3-<3-(dimethylamino)propyl>-1-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole hydrate, tributylicosanoylammonium sulphate / CH₂Cl₂ / 1) 0 deg C, 1 h; 2) 20 deg C, ca. 12 h

3: 99 percent / 3 percent HCl / methanol / 0.42 h / Heating

4: 96 percent / triethylamine, 3-<3-(dimethylamino)propyl>-1-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole hydrate, tributylicosanoylammonium sulphate / CH₂Cl₂ / 1) 0 deg C; 2) 20 deg C

With hydrogenchloride; thionyl chloride; tributylcosanoyl ammonium sulphate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;

Reference yield:

: 111-83-1
1-bromo-octane

: 129851-11-2
2-[2-(6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-decanoylamino]-decanoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NaOEt / 24 h / Heating

2: HCl / dimethylformamide / 24 h / Heating

3: 91 percent / thionyl chloride / 24 h / Heating

4: 92 percent / triethylamine, 3-<3-(dimethylamino)propyl>-1-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole hydrate, tributylicosanoylammonium sulphate / CH₂Cl₂ / 1) 0 deg C, 1 h; 2) 20 deg C, ca. 12 h

5: 99 percent / 3 percent HCl / methanol / 0.42 h / Heating

6: 96 percent / triethylamine, 3-<3-(dimethylamino)propyl>-1-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole hydrate, tributylicosanoylammonium sulphate / CH₂Cl₂ / 1) 0 deg C; 2) 20 deg C

With hydrogenchloride; thionyl chloride; tributylcosanoyl ammonium sulphate; sodium ethanolate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;