2-chloro-1-(1-cyclohexyl-7-isopropyl-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Base Information

Chemical Name:2-chloro-1-(1-cyclohexyl-7-isopropyl-3,4-dihydroisoquinolin-2(1H)-yl)ethanone
CAS No.:1085538-99-3
Molecular Formula:C₂₀H₂₈ClNO
Molecular Weight:333.901
Hs Code.:

Synonyms:2-chloro-1-(1-cyclohexyl-7-isopropyl-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

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Chemical Property of 2-chloro-1-(1-cyclohexyl-7-isopropyl-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

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Technology Process of 2-chloro-1-(1-cyclohexyl-7-isopropyl-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

There total 4 articles about 2-chloro-1-(1-cyclohexyl-7-isopropyl-3,4-dihydroisoquinolin-2(1H)-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: Tebbe's reagent

: 1085538-98-2
1-(1-cyclohexyl-3,4-dihydroisoquinolin-7-yl)ethanone

: 79-04-9
chloroacetyl chloride

: 1085538-99-3
2-chloro-1-(1-cyclohexyl-7-isopropyl-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Guidance literature:: Tebbe's reagent; 1-(1-cyclohexyl-3,4-dihydroisoquinolin-7-yl)ethanone; In tetrahydrofuran; toluene; at 20 ℃; for 0.75h;

With 20% palladium hydroxide-activated charcoal; hydrogen; In ethanol; at 20 ℃; for 13h;

chloroacetyl chloride; In ethyl acetate; at 4 - 20 ℃;
DOI:10.1016/j.bmc.2015.05.053

Reference yield:

: 1017150-11-6
C₁₈H₂₇N

: 79-04-9
chloroacetyl chloride

: 1085538-99-3
2-chloro-1-(1-cyclohexyl-7-isopropyl-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Guidance literature:: With sodium hydrogencarbonate; In water; ethyl acetate; for 1.08333h;

Reference yield:

: 823236-14-2
7-bromo-1-cyclohexyl-3,4-dihydroisoquinoline

: 1085538-99-3
2-chloro-1-(1-cyclohexyl-7-isopropyl-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride / 1,4-dioxane / 18 h / 80 °C

1.2: 0.5 h / 80 °C

2.1: tetrahydrofuran; toluene / 0.75 h / 20 °C

2.2: 13 h / 20 °C

2.3: 4 - 20 °C

With potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; toluene;
DOI:10.1016/j.bmc.2015.05.053