[2-amino-6-[4,5-difluoro-2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone

Base Information

Chemical Name:[2-amino-6-[4,5-difluoro-2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone
CAS No.:1367454-32-7
Molecular Formula:C₂₄H₁₈F₂N₄O₂
Molecular Weight:432.429
Hs Code.:

Synonyms:[2-amino-6-[4,5-difluoro-2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone

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Chemical Property of [2-amino-6-[4,5-difluoro-2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone

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Technology Process of [2-amino-6-[4,5-difluoro-2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone

There total 5 articles about [2-amino-6-[4,5-difluoro-2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 476620-55-0
(2-bromo-4,5-difluorophenyl)methanol

: 1228311-57-6
[2-amino-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone

: 1367454-32-7
[2-amino-6-[4,5-difluoro-2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In ethanol; water; at 120 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 20780-76-1
5-iodoisatin

: 1367454-32-7
[2-amino-6-[4,5-difluoro-2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 16 h / 10 - 23 °C

2: tetrahydrofuran / 0.5 h / 25 °C

3: cesium fluoride / acetonitrile / 0.33 h / 20 °C / Inert atmosphere

4: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / ethanol; water / 0.5 h / 120 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; potassium carbonate; cesium fluoride; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; acetonitrile; 5: |Suzuki Coupling;

Reference yield:

: 1228311-56-5
tert-butyl 5-iodo-2,3-dioxo-2,3-dihydroindole-1-carboxylate

: 1367454-32-7
[2-amino-6-[4,5-difluoro-2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 0.5 h / 25 °C

2: cesium fluoride / acetonitrile / 0.33 h / 20 °C / Inert atmosphere

3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / ethanol; water / 0.5 h / 120 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; potassium carbonate; cesium fluoride; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; acetonitrile; 4: |Suzuki Coupling;