2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl 3-dimethylaminopropionate

Base Information

Chemical Name:2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl 3-dimethylaminopropionate
CAS No.:1367454-94-1
Molecular Formula:C₂₉H₂₇F₂N₅O₃
Molecular Weight:531.562
Hs Code.:

Synonyms:2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl 3-dimethylaminopropionate

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Chemical Property of 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl 3-dimethylaminopropionate

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Technology Process of 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl 3-dimethylaminopropionate

There total 6 articles about 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl 3-dimethylaminopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1367454-32-7
[2-amino-6-[4,5-difluoro-2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone

: 14788-12-6
3-(dimethylamino)propanoic acid hydrochloride

: 1367454-94-1
2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl 3-dimethylaminopropionate

Guidance literature:: 3-(dimethylamino)propanoic acid hydrochloride; With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 25 ℃; for 1h;

[2-amino-6-[4,5-difluoro-2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone; With dmap; In tetrahydrofuran; dichloromethane; at 25 ℃; for 16h;

Reference yield:

: 1228311-57-6
[2-amino-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone

: 1367454-94-1
2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl 3-dimethylaminopropionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / ethanol; water / 0.5 h / 120 °C / Inert atmosphere

2.1: triethylamine; dicyclohexyl-carbodiimide / dichloromethane / 1 h / 25 °C

2.2: 16 h / 25 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; water; 1.1: |Suzuki Coupling;

Reference yield:

: 20780-76-1
5-iodoisatin

: 1367454-94-1
2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl 3-dimethylaminopropionate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 16 h / 10 - 23 °C

2.1: tetrahydrofuran / 0.5 h / 25 °C

3.1: cesium fluoride / acetonitrile / 0.33 h / 20 °C / Inert atmosphere

4.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / ethanol; water / 0.5 h / 120 °C / Inert atmosphere

6.1: triethylamine; dicyclohexyl-carbodiimide / dichloromethane / 1 h / 25 °C

6.2: 16 h / 25 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; cesium fluoride; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile; 5.1: |Suzuki Coupling;