3-aminomethyl-2-oxazol-2-yl-1-phenyl-1H-[1,8]naphthyridin-4-one bis(tert-butyl carbamate)

Base Information

Chemical Name:3-aminomethyl-2-oxazol-2-yl-1-phenyl-1H-[1,8]naphthyridin-4-one bis(tert-butyl carbamate)
CAS No.:1418025-76-9
Molecular Formula:C₂₈H₃₀N₄O₆
Molecular Weight:518.569
Hs Code.:

Synonyms:3-aminomethyl-2-oxazol-2-yl-1-phenyl-1H-[1,8]naphthyridin-4-one bis(tert-butyl carbamate)

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Chemical Property of 3-aminomethyl-2-oxazol-2-yl-1-phenyl-1H-[1,8]naphthyridin-4-one bis(tert-butyl carbamate)

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Technology Process of 3-aminomethyl-2-oxazol-2-yl-1-phenyl-1H-[1,8]naphthyridin-4-one bis(tert-butyl carbamate)

There total 5 articles about 3-aminomethyl-2-oxazol-2-yl-1-phenyl-1H-[1,8]naphthyridin-4-one bis(tert-butyl carbamate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.8%

: 51779-32-9
iminodicarboxylic acid di-tert-butyl ester

: 1418025-75-8
3-bromomethyl-2-oxazol-2-yl-1-phenyl-1H-[1,8]naphthyridin-4-one

: 1418025-76-9
3-aminomethyl-2-oxazol-2-yl-1-phenyl-1H-[1,8]naphthyridin-4-one bis(tert-butyl carbamate)

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 45 ℃; under 760.051 Torr; Inert atmosphere;

Reference yield:

: 131109-74-5
1-(2-chloro-pyridin-3-yl)propan-1-one

: 1418025-76-9
3-aminomethyl-2-oxazol-2-yl-1-phenyl-1H-[1,8]naphthyridin-4-one bis(tert-butyl carbamate)

Guidance literature:: Multi-step reaction with 4 steps

1: (1S)-(+)-10-camphorsulfonic acid / 1,4-dioxane / 95 °C / 760.05 Torr / Inert atmosphere; Sealed tube

2: sodium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 25 °C / 760.05 Torr / Inert atmosphere

3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / 90 °C / 760.05 Torr / Inert atmosphere

4: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran; mineral oil / 45 °C / 760.05 Torr / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); (1S)-(+)-10-camphorsulfonic acid; sodium hexamethyldisilazane; sodium hydride; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1418025-73-6
1-(2-phenylamino-pyridin-3-yl)propan-1-one

: 1418025-76-9
3-aminomethyl-2-oxazol-2-yl-1-phenyl-1H-[1,8]naphthyridin-4-one bis(tert-butyl carbamate)

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 25 °C / 760.05 Torr / Inert atmosphere

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / 90 °C / 760.05 Torr / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran; mineral oil / 45 °C / 760.05 Torr / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hexamethyldisilazane; sodium hydride; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide; mineral oil;