(E)-N-[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]-3-(4-nitrophenyl)acrylamide

Base Information

• Chemical Name: (E)-N-[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]-3-(4-nitrophenyl)acrylamide
• CAS No.: 1580002-71-6
• Molecular Formula: C₂₁H₂₃FN₄O₃
• Molecular Weight: 398.437

Synonyms:(E)-N-[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]-3-(4-nitrophenyl)acrylamide

Chemical Property of (E)-N-[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]-3-(4-nitrophenyl)acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]-3-(4-nitrophenyl)acrylamide

There total 5 articles about (E)-N-[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]-3-(4-nitrophenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.1%

4-(4-ethylpiperazin-1-yl)-3-fluoroaniline (873537-27-0) + (E)-4-nitrocinnamic acid chloride (22440-58-0,61921-33-3) → (E)-N-[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]-3-(4-nitrophenyl)acrylamide (1580002-71-6)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.ejmech.2014.01.024

Reference yield:

3,4-difluoronitrobenzene (369-34-6) → (E)-N-[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]-3-(4-nitrophenyl)acrylamide (1580002-71-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 12 h / 90 °C

2: hydrogen; palladium 10% on activated carbon / ethyl acetate; methanol / 6 h / 5171.62 Torr

3: pyridine / dichloromethane / 3 h / 0 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;

DOI:10.1016/j.ejmech.2014.01.024

Reference yield:

4-ethylpiperazine (5308-25-8) → (E)-N-[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]-3-(4-nitrophenyl)acrylamide (1580002-71-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 12 h / 90 °C

2: hydrogen; palladium 10% on activated carbon / ethyl acetate; methanol / 6 h / 5171.62 Torr

3: pyridine / dichloromethane / 3 h / 0 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;

DOI:10.1016/j.ejmech.2014.01.024

upstream raw materials:

3,4-difluoronitrobenzene

4-ethylpiperazine

1-ethyl-4-(2-fluoro-4-nitro-phenyl)-piperazine

4-(4-ethylpiperazin-1-yl)-3-fluoroaniline

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1580002-71-6 (E)-N-[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]-3-(4-nitrophenyl)acrylamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send