4-((7-(2-fluoroethoxy)-6-methoxyisoquinolin-1-yl)methyl)-2-methoxyphenol

Base Information

Chemical Name:4-((7-(2-fluoroethoxy)-6-methoxyisoquinolin-1-yl)methyl)-2-methoxyphenol
CAS No.:1335093-87-2
Molecular Formula:C₂₀H₂₀FNO₄
Molecular Weight:357.382
Hs Code.:

Synonyms:4-((7-(2-fluoroethoxy)-6-methoxyisoquinolin-1-yl)methyl)-2-methoxyphenol

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Chemical Property of 4-((7-(2-fluoroethoxy)-6-methoxyisoquinolin-1-yl)methyl)-2-methoxyphenol

Chemical Property:

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Technology Process of 4-((7-(2-fluoroethoxy)-6-methoxyisoquinolin-1-yl)methyl)-2-methoxyphenol

There total 7 articles about 4-((7-(2-fluoroethoxy)-6-methoxyisoquinolin-1-yl)methyl)-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1335093-51-0
1-(4-(benzyloxy)-3-methoxybenzyl)-7-(2-fluoroethoxy)-6-methoxyisoquinoline

: 1335093-87-2
4-((7-(2-fluoroethoxy)-6-methoxyisoquinolin-1-yl)methyl)-2-methoxyphenol

Guidance literature:: With hydrogenchloride; In ethanol; water; for 2h; Reflux; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.05.072

Reference yield:

: 914394-64-2
4-(2-fluoroethoxy)-3-methoxybenzaldehyde

: 1335093-87-2
4-((7-(2-fluoroethoxy)-6-methoxyisoquinolin-1-yl)methyl)-2-methoxyphenol

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium acetate; acetic acid / 0.5 h / Reflux; Inert atmosphere

2.1: tetrahydrofuran; methanol / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / Reflux; Inert atmosphere

4.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / 20 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: trichlorophosphate / acetonitrile / 0.5 h / Reflux; Inert atmosphere

6.1: hydrogenchloride / ethanol; water / 2 h / Reflux; Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; ammonium acetate; acetic acid; 1,1'-carbonyldiimidazole; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.ejmech.2011.05.072

Reference yield:

: 1335093-86-1
2-(4-(benzyloxy)-3-methoxyphenyl)-N-(2-(4-(2-fluoroethoxy)-3-methoxyphenyl)-2-methoxyethyl)acetamide

: 1335093-87-2
4-((7-(2-fluoroethoxy)-6-methoxyisoquinolin-1-yl)methyl)-2-methoxyphenol

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / acetonitrile / 0.5 h / Reflux; Inert atmosphere

2: hydrogenchloride / ethanol; water / 2 h / Reflux; Inert atmosphere

With hydrogenchloride; trichlorophosphate; In ethanol; water; acetonitrile;
DOI:10.1016/j.ejmech.2011.05.072