2-({3-[(2-azidoethyl)sulfanyl]-2-methylbenzyl}sulfanyl)-1H-benzimidazole

Base Information

Chemical Name:2-({3-[(2-azidoethyl)sulfanyl]-2-methylbenzyl}sulfanyl)-1H-benzimidazole
CAS No.:339354-73-3
Molecular Formula:C₁₇H₁₇N₅S₂
Molecular Weight:355.487
Hs Code.:

Synonyms:2-({3-[(2-azidoethyl)sulfanyl]-2-methylbenzyl}sulfanyl)-1H-benzimidazole

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Chemical Property of 2-({3-[(2-azidoethyl)sulfanyl]-2-methylbenzyl}sulfanyl)-1H-benzimidazole

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Technology Process of 2-({3-[(2-azidoethyl)sulfanyl]-2-methylbenzyl}sulfanyl)-1H-benzimidazole

There total 6 articles about 2-({3-[(2-azidoethyl)sulfanyl]-2-methylbenzyl}sulfanyl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 339353-47-8
2-[3-(1H-benzoimidazol-2-ylsulfanylmethyl)-2-methyl-phenylsulfanyl]-ethanol

: 339354-73-3
2-({3-[(2-azidoethyl)sulfanyl]-2-methylbenzyl}sulfanyl)-1H-benzimidazole

Guidance literature:: With sodium azide; carbon tetrabromide; triphenylphosphine; In N,N-dimethyl-formamide; for 18h;
DOI:10.1021/jm020868v

Reference yield:

: 52130-17-3
3-amino-2-methylbenzoic acid

: 339354-73-3
2-({3-[(2-azidoethyl)sulfanyl]-2-methylbenzyl}sulfanyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: HCl; NaNO₂ / H₂O / 0 °C

1.2: Na₂CO₃ / methanol; H₂O / 0.75 h / 60 - 70 °C / pH 5 - 6

2.1: 5 g / BH₃*THF / 1 h / 0 °C

3.1: thionyl chloride / CH₂Cl₂ / 4 h / 20 °C

4.1: 4.2 g / NaOH / H₂O; methanol / 6 h / 20 °C

5.1: 78 percent / LAH / tetrahydrofuran / 0.5 h / 0 °C

6.1: 48 percent / triphenylphosphine; sodium azide; CBr₄ / dimethylformamide / 18 h

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; sodium azide; borane-THF; carbon tetrabromide; triphenylphosphine; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm020868v

Reference yield:

: 339354-71-1
methyl 2-{[3-(chloromethyl)-2-methylphenyl]sulfanyl}acetate

: 339354-73-3
2-({3-[(2-azidoethyl)sulfanyl]-2-methylbenzyl}sulfanyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: 4.2 g / NaOH / H₂O; methanol / 6 h / 20 °C

2: 78 percent / LAH / tetrahydrofuran / 0.5 h / 0 °C

3: 48 percent / triphenylphosphine; sodium azide; CBr₄ / dimethylformamide / 18 h

With sodium hydroxide; lithium aluminium tetrahydride; sodium azide; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm020868v