52130-17-3

Usage

Chemical Properties

white to beige powder

InChI:InChI=1/C8H9NO2/c1-5-6(8(10)11)3-2-4-7(5)9/h2-4H,9H2,1H3,(H,10,11)/p-1

Upstream product

• 1975-50-4 2-methyl-3-nitrobenzic acid 
• 18583-89-6 methyl 3-amino-2-methylbenzoate 

Downstream Products

• 168899-41-0 3-N-(Methylsulfonyl)amino-2-methyl benzoic acid 
• 133232-56-1 3-iodo-2-methylbenzoic acid 
• 230300-07-9 3-amino-N-{3-[isobutyl-(4-methoxy-benzenesulfonyl)-amino]-2-oxo-propyl}-2-methyl-benzamide 
• 55289-06-0 3-methoxy-2-methylbenzoic acid 
• 230300-11-5 3-amino-N-{3-[isobutyl-(4-methoxy-benzenesulfonyl)-amino]-2-oxo-1-phenylsulfanyl-propyl}-2-methyl-benzamide 
• 204782-99-0 8-methyl-7-quinolinecarboxylic acid 
• 18583-89-6 methyl 3-amino-2-methylbenzoate 
• 306276-93-7 2-methylamino-4-methylbenzothiazole-5-carboxylic acid 
• 55-21-0 benzamide 
• 1445799-98-3 3-(5-acetylfuran-2-yl)-2-methylbenzoic acid 
• 462068-41-3 3-(5-formylfuran-2-yl)-2-methylbenzoic acid 

Relevant academic research and scientific papers

Co-production process of methyl 3-hydroxy-2-methyl benzoate and methyl 3-methoxy-2-methyl benzoate

The invention discloses a co-production process of 3-hydroxy-2-methyl benzoate and 3-methoxy-2-methyl benzoate, which comprises the following steps: (1) reduction hydrogenation reaction: by taking 2-methyl-3-nitrobenzoic acid or methyl 2-methyl-3-nitroben

Synthesis process 2 - methyl -3 - methoxybenzoic acid

The invention discloses a synthesis process of 2 - methyl -3 - methoxybenzoic acid, which comprises the following steps: (1) reducing hydrogenation reaction: taking 2 - methyl -3 - nitrobenzoic acid or 2 - methyl -3 - nitrobenzoate as raw materials and methanol as a solvent. The hydrogen is a hydrogen source, and palladium carbon or platinum carbon is used as a catalyst to prepare 3 - amino -2 - methyl benzoic acid or 3 - amino -2 - methyl benzoic acid methyl ester by hydrogenation reduction. (2) Diazotization and hydrolysis and esterification one-pot reaction: preparing and hydroxyl 3 - methyl benzoic acid methyl ester by carrying out diazotization and hydrolysis -2 - esterification reaction under the action of a reducing product as a raw material and methanol as a solvent and a diazotization reagent. (3) Methylation reaction: methyl benzoate serving 3 - hydroxyl -2 - is used as a raw material, dimethyl sulfate is used as a methylation reagent, and methyl benzoate is produced 3 - methoxy -2 - methyl benzoate in the presence of a base. (4) Hydrolysis Reaction: methyl 3 - methoxy -2 - methyl benzoate and base. Water is mixed, heated and hydrolyzed, the reaction is complete, the product precipitated by acid conditioning PH through 1-3, filtered, and dried to obtain 3 - methoxy -2 -methylbenzoic acid.

Low-temperature nematic phase in azo functionalised reactive hockey stick mesogens possessing lateral methyl group

We report, the design, synthesis and mesomorphic behaviour of new hockey stick mesogens containing photochromic azo group and a reactive double bond. The structure of the compounds resemble the hockey stick due to unequal distribution of the phenyl rings

ROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF

The present disclosure relates to compounds of the general formula (I): wherein R1, R2, R3, R4, R5, R6, and R7 may be chosen from different substituents; n is 0, 1, or 2; and X is a hydroxymethyl or a carboxylic acid or a derivative thereof, such as a carboxylate, such as a carboxylic ester, a glyceride, an anhydride, a phospholipid, a carboxamide, a phospholipid, or a prodrug thereof; or a pharmaceutically acceptable salt, solvate, solvate of such salt or a prodrug thereof. The present disclosure also relates to pharmaceutical compositions and lipid compositions comprising at least one compound according to the present disclosure, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to metabolic diseases and liver diseases, such as non-alcoholic fatty liver disease and cholestasis diseases.

Novel achiral four-ring bent-shaped nematic liquid crystals with trifluoromethyl and methyl substituents in the central molecular core: An unusually large Kerr constant in blue phase III of nematic-chiral dopant mixture

Here, we report the first example of achiral bent-shaped liquid crystals comprising trifluoromethyl and methyl moieties on adjacent phenyl rings in the core, exhibiting nematic mesomorphism close to room temperature on cooling. The XRD confirms the existe

Design, synthesis and mesomorphic behaviour of a four-ring achiral bent-core liquid crystal in the nematic phase

Bent-core nematics have attracted growing interest because of the unconventional properties and extraordinary effects exhibited by these liquid crystalline phases. In this report we design, synthesize and characterize four different four-ring achiral bent

SMALL MOLECULE INHIBITORS OF TLR2 SIGNALING

The present invention is drawn to therapeutics and methods of inhibiting signaling by TLR2. The invention provides a method of treating an inflammatory disease or condition in a subject comprising administering to the subject a therapeutically effective amount of a compound of the invention or salt, solvate, hydrate, prodrug, metabolite, or combination thereof.

Synthesis and mesomorphic behaviour of achiral four-ring unsymmetrical bent-core liquid crystals: Nematic phases

Achiral four ring unsymmetrical bent-core liquid crystals derived from 3-amino-2-methylbenzoic acid have been designed and synthesized with an imine, ester and photochromic azo linking moieties. These hockey-stick shape resembling bent molecules possess a

Viscoelasticity, dielectric anisotropy, and birefringence in the nematic phase of three four-ring bent-core liquid crystals with an L-shaped molecular frame

Molecular shape is an important factor in determining the material properties of thermotropic liquid crystals (LCs). We synthesized and investigated several LC compounds formed by asymmetrically bent molecules with a rigid four-ring core in the shape of t

Nematic phases in achiral unsymmetrical four-ring bent-core azo compounds possessing strongly polar cyano and nitro moieties as end substituents: Synthesis and characterization

Achiral unsymmetrical four-ring bent-core liquid crystals with strongly polar cyano and nitro moieties as substituents at one end and alkyloxy group (butyl to dodecyl) at the other end have been synthesized by a simple and straight forward synthetic method. The four phenyl rings are connected through azo, ester and imine linkages respectively and bent unit is derived from 3-aminobenzoicacid with 2-methyl substituent in the transverse direction of the molecule. The molecular structure characterization is consistent with elemental and spectroscopic analysis data. The materials thermal behaviour and phase characterization have been investigated by differential scanning calorimetry and polarizing optical microscopy. All the compounds exhibit enantiotropic nematic phase over a wide temperature range. The light induced cis-trans isomerization is also discussed.