(3S)-ethyl 4-((2R,4R,6R)-6-ethyl-2-phenyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)-2,2-dimethylbutanoate

Base Information

Chemical Name:(3S)-ethyl 4-((2R,4R,6R)-6-ethyl-2-phenyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)-2,2-dimethylbutanoate
CAS No.:1332478-27-9
Molecular Formula:C₂₂H₃₄O₆
Molecular Weight:394.508
Hs Code.:

Synonyms:(3S)-ethyl 4-((2R,4R,6R)-6-ethyl-2-phenyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)-2,2-dimethylbutanoate

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Chemical Property of (3S)-ethyl 4-((2R,4R,6R)-6-ethyl-2-phenyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)-2,2-dimethylbutanoate

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Technology Process of (3S)-ethyl 4-((2R,4R,6R)-6-ethyl-2-phenyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)-2,2-dimethylbutanoate

There total 3 articles about (3S)-ethyl 4-((2R,4R,6R)-6-ethyl-2-phenyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)-2,2-dimethylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1332478-26-8
(3S)-ethyl 4-((2R,4S,6R)-6-ethyl-2-phenyl-1,3-dioxan-4-yl)-3-hydroxy-2,2-dimethylbutanoate

: 107-30-2
chloromethyl methyl ether

: 1332478-27-9
(3S)-ethyl 4-((2R,4R,6R)-6-ethyl-2-phenyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)-2,2-dimethylbutanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 36h; Inert atmosphere;
DOI:10.1021/jo201210u

Reference yield:

: 1332478-25-7
2-((2R,4R,6R)-6-ethyl-2-phenyl-1,3-dioxan-4-yl)acetaldehyde

: 1332478-27-9
(3S)-ethyl 4-((2R,4R,6R)-6-ethyl-2-phenyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)-2,2-dimethylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / -78 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 36 h / 0 - 20 °C / Inert atmosphere

With boron trifluoride diethyl etherate; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1: Mukaiyama aldol reaction;
DOI:10.1021/jo201210u

Reference yield:

: 31469-16-6
1-ethoxy-1-((trimethylsilyl)oxy)-2-methylpropene

: 1332478-27-9
(3S)-ethyl 4-((2R,4R,6R)-6-ethyl-2-phenyl-1,3-dioxan-4-yl)-3-(methoxymethoxy)-2,2-dimethylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / -78 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 36 h / 0 - 20 °C / Inert atmosphere

With boron trifluoride diethyl etherate; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1: Mukaiyama aldol reaction;
DOI:10.1021/jo201210u