N-[(1S, 2S)-2-[[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]amino]cyclohexyl]acetamide

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Chemical Name:N-[(1S, 2S)-2-[[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]amino]cyclohexyl]acetamide
CAS No.:1259277-59-2
Molecular Formula:C₁₉H₂₀ClFN₆O
Molecular Weight:402.859
Hs Code.:

Synonyms:N-[(1S, 2S)-2-[[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]amino]cyclohexyl]acetamide

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Chemical Property of N-[(1S, 2S)-2-[[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]amino]cyclohexyl]acetamide

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Technology Process of N-[(1S, 2S)-2-[[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]amino]cyclohexyl]acetamide

There total 9 articles about N-[(1S, 2S)-2-[[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]amino]cyclohexyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: C₂₆H₂₆ClFN₆O₃S

: 1259277-59-2
N-[(1S, 2S)-2-[[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]amino]cyclohexyl]acetamide

Guidance literature:: With lithium hydroxide; In 1,2-dichloro-ethane; at 150 ℃; for 0.166667h; Microwave irradiation;
DOI:10.1021/jm5007275

Reference yield: 44.0%

: IPr₂NEt

: 1259277-58-1
(1S,2S)-N₁-(2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl)cyclohexane-1,2-diamine

: 75-36-5
acetyl chloride

: 1259277-59-2
N-[(1S, 2S)-2-[[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]amino]cyclohexyl]acetamide

Guidance literature:: With LiOH; In 1,1-dichloroethane; dichloromethane;

Reference yield:

: 1259012-01-5
5-chloro-3-(5-fluoro-4-methylsulfinyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine

: 1259277-59-2
N-[(1S, 2S)-2-[[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]amino]cyclohexyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0.33 h / 140 °C / Sealed tube

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

3: lithium hydroxide / 1,2-dichloro-ethane / 0.17 h / 150 °C / Microwave irradiation

With N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm5007275