2-thiomethylpyrimidin-4-yl-4-fluorophenylbenzil

Base Information

• Chemical Name: 2-thiomethylpyrimidin-4-yl-4-fluorophenylbenzil
• CAS No.: 218162-50-6
• Molecular Formula: C₁₃H₉FN₂O₂S
• Molecular Weight: 276.291
• Mol file: 218162-50-6.mol

Synonyms:2-thiomethylpyrimidin-4-yl-4-fluorophenylbenzil

Chemical Property of 2-thiomethylpyrimidin-4-yl-4-fluorophenylbenzil

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-thiomethylpyrimidin-4-yl-4-fluorophenylbenzil

There total 5 articles about 2-thiomethylpyrimidin-4-yl-4-fluorophenylbenzil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-(4-fluorophenyl)-2-(2-methylsulphanylpyrimidin-4-yl)-1-ethanone (217661-99-9) → 2-thiomethylpyrimidin-4-yl-4-fluorophenylbenzil (218162-50-6)

Guidance literature:

With hydrogen bromide; dimethyl sulfoxide; at 65 ℃;

DOI:10.1016/S0960-894X(01)00034-8

Reference yield:

2-methylthio-4-methylpyrimidine (14001-63-9) → 2-thiomethylpyrimidin-4-yl-4-fluorophenylbenzil (218162-50-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaHMDS / tetrahydrofuran / 0.5 h / 0 °C

1.2: 99 percent / tetrahydrofuran / 3 h / 20 °C

2.1: 82 percent / 48percent HBr; DMSO / 3 h / 55 °C

With sodium hexamethyldisilazane; dimethyl sulfoxide; In tetrahydrofuran;

DOI:10.1021/jm011132l

Reference yield:

methyl 4-flurobenzoate (403-33-8) → 2-thiomethylpyrimidin-4-yl-4-fluorophenylbenzil (218162-50-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaHMDS / tetrahydrofuran / 0.5 h / 0 °C

1.2: 99 percent / tetrahydrofuran / 3 h / 20 °C

2.1: 82 percent / 48percent HBr; DMSO / 3 h / 55 °C

With sodium hexamethyldisilazane; dimethyl sulfoxide; In tetrahydrofuran;

DOI:10.1021/jm011132l

upstream raw materials:

1-(4-fluorophenyl)-2-(2-methylsulphanylpyrimidin-4-yl)-1-ethanone

2-methylthio-4-methylpyrimidine

methyl 4-flurobenzoate

4-fluorobenzoic acid ethyl ester

Downstream raw materials:

4-(4-fluoro-phenyl)-5-(2-methylsulfanyl-pyrimidin-4-yl)-1H-imidazole-2-carbaldehyde

C₂₀H₁₅FN₄OS

C₂₂H₁₅FN₄S

3-((4-(4-fluorophenyl)-5-(2-(methylthio)-pyrimidin-4-yl)-1H-imidazol-2-yl)methyl)benzonitrile