Technology Process of 2-<4-iodo-3-(methoxymethoxy)phenyl>-1,3-dioxane
There total 1 articles about 2-<4-iodo-3-(methoxymethoxy)phenyl>-1,3-dioxane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; ethylene iodochloride;
In
diethyl ether;
at -78 ℃;
Product distribution;
without TMEDA, other metallating agent, solvent and temperature;
DOI:10.1016/S0040-4020(01)91921-0
- Guidance literature:
-
With
hydrogenchloride;
In
tetrahydrofuran;
at 20 ℃;
for 40h;
DOI:10.1039/b708449h
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 88 percent / aq. HCl / tetrahydrofuran / 40 h / 20 °C
2: 91 percent / cesium carbonate / dimethylformamide / 0.25 h / 90 °C
3: 91 percent / NaClO2; NaH2PO4; aq. H2O2 / acetonitrile / 2 h / 20 °C
4: 100 percent / i-Pr2NEt; HATU / dimethylformamide / 1 h / 20 °C
5: Et3N / PdCl2(dppf) / acetonitrile / 1 h / Heating
6: 0.16 g / KHF2 / methanol; H2O / 2 h / 20 °C
With
hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; potassium hydrogen bifluoride; dihydrogen peroxide; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b708449h
