5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-2-carboxylic acid

Base Information

Chemical Name:5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-2-carboxylic acid
CAS No.:1093631-53-8
Molecular Formula:C₂₈H₂₁Cl₂NO₄S
Molecular Weight:538.451
Hs Code.:

Synonyms:5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-2-carboxylic acid

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Chemical Property of 5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-2-carboxylic acid

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Technology Process of 5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-2-carboxylic acid

There total 3 articles about 5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 7312-10-9
5-bromo-1-benzothiophene-2-carboxylic acid

: 1020576-09-3
3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-({[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]oxy}methyl)isoxazole

: 1093631-53-8
5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-2-carboxylic acid

Guidance literature:: 5-bromo-1-benzothiophene-2-carboxylic acid; 3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-({[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]oxy}methyl)isoxazole; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 85 ℃; for 4h; Inert atmosphere;

With hydrogenchloride; In dichloromethane; water; at 20 ℃; pH=2 - 3;

Reference yield:

: 278597-30-1
[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methanol

: 1093631-53-8
5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: di-isopropyl azodicarboxylate / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 4 h / 85 °C / Inert atmosphere

2.2: 20 °C / pH 2 - 3

With di-isopropyl azodicarboxylate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; 1.1: Mitsunobu reaction / 2.1: Suzuki Coupling;

Reference yield:

: 269409-70-3
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1093631-53-8
5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1-benzothiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: di-isopropyl azodicarboxylate / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 4 h / 85 °C / Inert atmosphere

2.2: 20 °C / pH 2 - 3

With di-isopropyl azodicarboxylate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; 1.1: Mitsunobu reaction / 2.1: Suzuki Coupling;