2-[(4S,5R,6R)-7-(2,2-Dimethyl-propionyloxy)-3-hydroxy-4,5,6-tris-methoxymethoxy-hept-1-ynyl]-4-methoxy-6-methoxymethoxy-benzoic acid methyl ester

Base Information

Chemical Name:2-[(4S,5R,6R)-7-(2,2-Dimethyl-propionyloxy)-3-hydroxy-4,5,6-tris-methoxymethoxy-hept-1-ynyl]-4-methoxy-6-methoxymethoxy-benzoic acid methyl ester
CAS No.:335058-63-4
Molecular Formula:C₂₉H₄₄O₁₄
Molecular Weight:616.66
Hs Code.:

2-[(4S,5R,6R)-7-(2,2-Dimethyl-propionyloxy)-3-hydroxy-4,5,6-tris-methoxymethoxy-hept-1-ynyl]-4-methoxy-6-methoxymethoxy-benzoic acid methyl ester

Synonyms:2-[(4S,5R,6R)-7-(2,2-Dimethyl-propionyloxy)-3-hydroxy-4,5,6-tris-methoxymethoxy-hept-1-ynyl]-4-methoxy-6-methoxymethoxy-benzoic acid methyl ester

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Chemical Property of 2-[(4S,5R,6R)-7-(2,2-Dimethyl-propionyloxy)-3-hydroxy-4,5,6-tris-methoxymethoxy-hept-1-ynyl]-4-methoxy-6-methoxymethoxy-benzoic acid methyl ester

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Technology Process of 2-[(4S,5R,6R)-7-(2,2-Dimethyl-propionyloxy)-3-hydroxy-4,5,6-tris-methoxymethoxy-hept-1-ynyl]-4-methoxy-6-methoxymethoxy-benzoic acid methyl ester

There total 8 articles about 2-[(4S,5R,6R)-7-(2,2-Dimethyl-propionyloxy)-3-hydroxy-4,5,6-tris-methoxymethoxy-hept-1-ynyl]-4-methoxy-6-methoxymethoxy-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2-iodo-4-methoxy-6-methoxymethoxy-benzoic acid methyl ester

: 335058-56-5
2,2-Dimethyl-propionic acid (2R,3R,4S)-5-hydroxy-2,3,4-tris-methoxymethoxy-hept-6-ynyl ester

: 335058-63-4
2-[(4S,5R,6R)-7-(2,2-Dimethyl-propionyloxy)-3-hydroxy-4,5,6-tris-methoxymethoxy-hept-1-ynyl]-4-methoxy-6-methoxymethoxy-benzoic acid methyl ester

Guidance literature:: With copper(l) iodide; triethylamine; triphenylphosphine; palladium diacetate; for 2h;
DOI:10.1246/cl.2001.172

Reference yield:

: 335058-46-3
Benzyl-β-D-ribopyranosid

: 335058-63-4
2-[(4S,5R,6R)-7-(2,2-Dimethyl-propionyloxy)-3-hydroxy-4,5,6-tris-methoxymethoxy-hept-1-ynyl]-4-methoxy-6-methoxymethoxy-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / i-Pr₂NEt / acetonitrile / 4 h / 50 °C

2: 100 percent / H₂ / Pd(OH)2 / ethanol / 3 h

3: n-BuLi; BF₃*Et₂O / tetrahydrofuran / -78 - 20 °C

4: pyridine / 1 h / 0 °C

5: 100 percent / TBAF / acetic acid; tetrahydrofuran / 2 h

6: 85 percent / CuI; Ph₃P; Et₃N / Pd(OAc)2 / 2 h

With copper(l) iodide; n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium diacetate; palladium dihydroxide; In tetrahydrofuran; pyridine; ethanol; acetic acid; acetonitrile; 6: Sonogashira coupling;
DOI:10.1246/cl.2001.172

Reference yield:

: 10257-32-6
D-ribose

: 335058-63-4
2-[(4S,5R,6R)-7-(2,2-Dimethyl-propionyloxy)-3-hydroxy-4,5,6-tris-methoxymethoxy-hept-1-ynyl]-4-methoxy-6-methoxymethoxy-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 89 percent / CSA / 80 °C

2: 85 percent / i-Pr₂NEt / acetonitrile / 4 h / 50 °C

3: 100 percent / H₂ / Pd(OH)2 / ethanol / 3 h

4: n-BuLi; BF₃*Et₂O / tetrahydrofuran / -78 - 20 °C

5: pyridine / 1 h / 0 °C

6: 100 percent / TBAF / acetic acid; tetrahydrofuran / 2 h

7: 85 percent / CuI; Ph₃P; Et₃N / Pd(OAc)2 / 2 h

With copper(l) iodide; n-butyllithium; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium diacetate; palladium dihydroxide; In tetrahydrofuran; pyridine; ethanol; acetic acid; acetonitrile; 7: Sonogashira coupling;
DOI:10.1246/cl.2001.172