(1S,2S,4S)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide

Base Information

Chemical Name:(1S,2S,4S)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide
CAS No.:190316-04-2
Molecular Formula:C₁₈H₂₆N₄O₃
Molecular Weight:346.429
Hs Code.:

Synonyms:(1S,2S,4S)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide

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Chemical Property of (1S,2S,4S)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide

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Technology Process of (1S,2S,4S)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide

There total 1 articles about (1S,2S,4S)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120-74-1,934-30-5,1195-12-6,20507-53-3,58001-99-3,67999-50-2,67999-53-5,74645-32-2,108266-75-7
(1S,2S,4S)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid

: 190316-04-2
(1S,2S,4S)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 2.5 h / Ambient temperature

2: pyridine, DMAP / 2 h / Ambient temperature

With pyridine; dmap; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jm970013w

Reference yield:

: 190316-04-2
(1S,2S,4S)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide

: C₂₅H₂₇BrN₄O₄

Guidance literature:: Multi-step reaction with 4 steps

1: 2N aq. NaOH / dioxane / 4 h / Heating

2: 66 percent / magnesium monoperoxyphthalate / propan-2-ol; H₂O / 20 h / Ambient temperature

3: 83.5 percent / 6N aq. HCl / ethanol / 30 h / Ambient temperature

4: 86.8 percent / DMAP, pyridine / 20 h / 50 °C

With pyridine; hydrogenchloride; dmap; sodium hydroxide; magnesium monoperoxyphthalate hexahydrate; In 1,4-dioxane; ethanol; water; isopropyl alcohol;
DOI:10.1021/jm970013w

Reference yield:

: 190316-04-2
(1S,2S,4S)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide

: 190316-06-4,166374-48-7,166374-49-8
1,3-dipropyl-8-[5,6-exo-epoxy-(1S,2S)-norbornan-2-yl]xanthine

Guidance literature:: Multi-step reaction with 2 steps

1: 2N aq. NaOH / dioxane / 4 h / Heating

2: 66 percent / magnesium monoperoxyphthalate / propan-2-ol; H₂O / 20 h / Ambient temperature

With sodium hydroxide; magnesium monoperoxyphthalate hexahydrate; In 1,4-dioxane; water; isopropyl alcohol;
DOI:10.1021/jm970013w