2-Ethyl-hexanoic acid {1-[2-methoxy-4-(1H-tetrazol-5-yl)-benzyl]-1H-indazol-6-yl}-amide

Base Information

Chemical Name:2-Ethyl-hexanoic acid {1-[2-methoxy-4-(1H-tetrazol-5-yl)-benzyl]-1H-indazol-6-yl}-amide
CAS No.:104436-80-8
Molecular Formula:C₂₄H₂₉N₇O₂
Molecular Weight:447.54
Hs Code.:

Synonyms:2-Ethyl-hexanoic acid {1-[2-methoxy-4-(1H-tetrazol-5-yl)-benzyl]-1H-indazol-6-yl}-amide

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Chemical Property of 2-Ethyl-hexanoic acid {1-[2-methoxy-4-(1H-tetrazol-5-yl)-benzyl]-1H-indazol-6-yl}-amide

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Technology Process of 2-Ethyl-hexanoic acid {1-[2-methoxy-4-(1H-tetrazol-5-yl)-benzyl]-1H-indazol-6-yl}-amide

There total 7 articles about 2-Ethyl-hexanoic acid {1-[2-methoxy-4-(1H-tetrazol-5-yl)-benzyl]-1H-indazol-6-yl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 104436-67-1
6-amino-1-<2-methoxy-4-(1H-tetrazol-5-yl)benzyl>indole

: 760-67-8
2-ethylhexanoic acid chloride

: 104436-80-8
2-Ethyl-hexanoic acid {1-[2-methoxy-4-(1H-tetrazol-5-yl)-benzyl]-1H-indazol-6-yl}-amide

Guidance literature:: With 2,6-dimethylpyridine; 1-methyl-pyrrolidin-2-one; In tetrahydrofuran; 1.) from 0 deg C to RT, 2 h, 2.) RT, 14 h;
DOI:10.1021/jm00171a018

Reference yield:

: 4769-96-4
6-nitroindole

: 104436-80-8
2-Ethyl-hexanoic acid {1-[2-methoxy-4-(1H-tetrazol-5-yl)-benzyl]-1H-indazol-6-yl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / K₂CO₃ / acetone / Heating

2: 86 percent / sodium azide, Et₃N*HCl, N-methylpyrrolidone (NMP) / 3.5 h / 150 °C

3: 100 percent / H₂, 6 M KOH / 10percent Pd/C / methanol / 2 h / 2587.7 Torr

4: 56 percent / 2,6-lutidine, N-methylpyrrolidone (NMP) / tetrahydrofuran / 1.) from 0 deg C to RT, 2 h, 2.) RT, 14 h

With 2,6-dimethylpyridine; 1-methyl-pyrrolidin-2-one; potassium hydroxide; sodium azide; hydrogen; triethylamine hydrochloride; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; acetone;
DOI:10.1021/jm00171a018

Reference yield:

: 7151-68-0
3-methoxy-p-toluic acid

: 104436-80-8
2-Ethyl-hexanoic acid {1-[2-methoxy-4-(1H-tetrazol-5-yl)-benzyl]-1H-indazol-6-yl}-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / chlorosulfonyl isocyanate / CH₂Cl₂ / 0.75 h / Heating

2: 65 percent / N-bromosuccinimide (NBS), benzoyl peroxide / CCl₄ / 0.25 h / Heating; Irradiation

3: 90 percent / K₂CO₃ / acetone / Heating

4: 86 percent / sodium azide, Et₃N*HCl, N-methylpyrrolidone (NMP) / 3.5 h / 150 °C

5: 100 percent / H₂, 6 M KOH / 10percent Pd/C / methanol / 2 h / 2587.7 Torr

6: 56 percent / 2,6-lutidine, N-methylpyrrolidone (NMP) / tetrahydrofuran / 1.) from 0 deg C to RT, 2 h, 2.) RT, 14 h

With 2,6-dimethylpyridine; 1-methyl-pyrrolidin-2-one; potassium hydroxide; N-Bromosuccinimide; sodium azide; Perbenzoic acid; isocyanate de chlorosulfonyle; hydrogen; triethylamine hydrochloride; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; acetone;
DOI:10.1021/jm00171a018