760-67-8

Basic information

• Product Name: 2-Ethylhexanoyl chloride
• Synonyms: 2-Ethylhexanoic acid, chloride;2-ethylhexanoicacidchloride;2-ethyl-hexanoylchlorid;2-ETHYLHEXANOYL CHLORIDE 99+%;2-Ethyl Capronyl Chloride;2-Ethylhexansurechlorid;2-Ethylhexanoyl chloride,98%;2-ETHYLHEXANOYL CHLORIDE FOR SYNTHESIS
• CAS NO: 760-67-8
• Molecular Formula: C₈H₁₅ClO
• Molecular Weight: 162.66
• EINECS: 212-081-1
• Product Categories: ACID CHLORIDES;Acid Halides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 760-67-8.mol
• Article Data: 14

Chemical Properties

• Melting Point: <-75°C
• Boiling Point: 67-68 °C11 mm Hg(lit.)
• Flash Point: 157 °F
• Appearance: Clear colourless to greyish liquid
• Density: 0.939 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.72 mm Hg ( 67.7 °C)
• Refractive Index: n20/D 1.433(lit.)
• Storage Temp.: Store below +30°C.
• Water Solubility: Reacts with water.
• Sensitive: Moisture Sensitive
• BRN: 956601
• CAS DataBase Reference: 2-Ethylhexanoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethylhexanoyl chloride(760-67-8)
• EPA Substance Registry System: 2-Ethylhexanoyl chloride(760-67-8)

Safety Data

• Hazard Codes: C
• Statements: 34-43-41-23-22
• Safety Statements: 26-36/37/39-45-25
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 1
• RTECS: MP4525000
• TSCA: Yes
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 760-67-8(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLOURLESS TO GREYISH LIQUID

Uses

2-Ethylhexanoyl chloride was used in the preparation of 4-aza-6-ethyl-4-(2-ethylhexanoyloxy)-5-oxodecyl 2,3, 4,6-tetra-O-acetyl-l-thio-β-D glucopyranoside. It was also used in the preparation of poly(4,8-bis-alkyloxybenzo(1,2-b:4,5-b?)dithiophene-2,6-diyl-alt-(alkyl thieno(3,4-b)thiophene-2-carboxylate)-2,6-diyl), having very promising photovoltaic properties.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C8H15ClO/c1-3-5-6-7(4-2)8(9)10/h7H,3-6H2,1-2H3/t7-/m0/s1

Upstream product

• 149-57-5 2-Ethylhexanoic acid 
• 93344-33-3 (S)ethyl-2-hexanoic acid (R)phenyl-1-ethylamine salt 
• 72377-05-0 (2S)-ethylhexanoic acid 
• 56006-48-5 R-(-)-2-ethylhexanoic acid 
• 7719-09-7 thionyl chloride 
• 551-16-6 6-aminopenicillanic acid 
• 695-19-2 N-methyl-4-pyridone 
• 75-44-5 phosgene 

Downstream Products

• 4164-92-5 (+)(S)-heptane-carboxylic acid-(3)-amide 
• 104436-05-7 6-(2-ethylhexanamido)indole 
• 51686-60-3 2-ethyl-5-methyl-cyclopentanone 
• 17180-41-5 hept-3-yl phenyl ketone 
• 6288-15-9 2-(2-ethyl-hexanoyloxy)-propionic acid amide 
• 105424-94-0 benzyl N-[2-ethylhexanoyl]-(L)-pyroglutamate 
• 104435-85-0 methyl 4-[6-(2-ethylhexanamido)indol-1-ylmethyl]-3-methoxybenzoate 
• 3006-82-4 tertiary butyl per-2-ethylhexanoate 
• 1072113-08-6 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(2-ethylhexanoyl)-4-methyl-1H-pyrazole-3-carboxamide 
• 486455-65-6 N-2-ethylhexanoyl-L-glutamic acid N,N'-(dibutylamide) 
• 1135295-17-8 C₃₁H₄₁BrN₄O₃ 
• 1135694-26-6 C₃₆H₄₄N₄O₃ 
• 1135265-89-2 C₃₆H₄₃BrN₄O₃ 
• 1169516-92-0 C₄₄H₆₂N₄O₁₂ 

Relevant articles and documents

LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS

Compounds are provided having the following structure (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, L1, L2, G1, G2, G3, a, b, c and d are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

Antifungal quinazolinones from marine-derived Bacillus cereus and their preparation

Two new quinazolinones alkaloids, R(+)-2-(heptan-3-yl)quinazolin-4(3H)-one (1) and (2R,3′R)+(2S,3′R)-2-(heptan-3-yl)-2,3-dihydroquinazolin- 4(1H)-one (2) (a pair of epimers), as well as seven known analogues, 2-methylquinazolin-4(3H)-one (3), 2-benzylquinazolin-4(3H)-one (4), cyclo-(Pro-Ile), cyclo-(Pro-Leu), cyclo-(Pro-Val), cyclo-(Pro-Phe), and cyclo-(Tyr-Pro) were isolated from the n-butyl alcohol extract of the marine-derived bacterium Bacillus cereus 041381. The new compounds were identified by spectroscopic analysis and chemical synthesis. Four optical isomers 5-8 were also synthesized. Compounds 1-8 all showed moderate antifungal activity against Candida albicans with MIC values of 1.3-15.6 μM. Compound 5 exhibits the most powerful antifungal activity, which may reveal that S-configuration and 2,3-double bond were necessary for antifungal activity, and the racemization at C-2 and C-3′ reduced the antifungal activity.

Syntheses and evaluation of anticonvulsant profile and teratogenicity of novel amide derivatives of branched aliphatic carboxylic acids with 4-aminobenzensulfonamide

Despite the availability of 14 new antiepileptic drugs (AEDs), about 30% of epileptic patients are not seizure-free. Consequently there is substantial need to develop new effective AEDs. A novel class of aromatic amides composed of phenylacetic acid or branched aliphatic carboxylic acids, with five to nine carbons in their carboxylic moiety, and aminobenzenesulfonamide were synthesized and evaluated in the anticonvulsant rat-maximal electroshock (MES) and subcutaneous metrazol seizure (scMet) tests. Fourteen of the synthesized amides had an anticonvulsant ED50 of 50 values of 7.6, 9.9, and 9.4 mg/kg and remarkable protective index (PI = TD 50/ED50) values of 65.7, 50.5, and 53.2, respectively. These potent sulfanylamides caused neural tube defects only at doses markedly exceeding their effective dose. The anticonvulsant properties of these compounds make them potential candidates for further development as new, potent, and safe AEDs.