(2S,3R)-2-{3-[((S)-5-Benzyloxycarbonylamino-5-methoxycarbonyl-pentyl)-methyl-carbamoyloxy]-propyl}-3-isobutyl-succinic acid 4-benzyl ester 1-tert-butyl ester

Base Information

Chemical Name:(2S,3R)-2-{3-[((S)-5-Benzyloxycarbonylamino-5-methoxycarbonyl-pentyl)-methyl-carbamoyloxy]-propyl}-3-isobutyl-succinic acid 4-benzyl ester 1-tert-butyl ester
CAS No.:191407-52-0
Molecular Formula:C₃₉H₅₆N₂O₁₀
Molecular Weight:712.881
Hs Code.:

(2S,3R)-2-{3-[((S)-5-Benzyloxycarbonylamino-5-methoxycarbonyl-pentyl)-methyl-carbamoyloxy]-propyl}-3-isobutyl-succinic acid 4-benzyl ester 1-tert-butyl ester

Synonyms:(2S,3R)-2-{3-[((S)-5-Benzyloxycarbonylamino-5-methoxycarbonyl-pentyl)-methyl-carbamoyloxy]-propyl}-3-isobutyl-succinic acid 4-benzyl ester 1-tert-butyl ester

Suppliers and Price of (2S,3R)-2-{3-[((S)-5-Benzyloxycarbonylamino-5-methoxycarbonyl-pentyl)-methyl-carbamoyloxy]-propyl}-3-isobutyl-succinic acid 4-benzyl ester 1-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R)-2-{3-[((S)-5-Benzyloxycarbonylamino-5-methoxycarbonyl-pentyl)-methyl-carbamoyloxy]-propyl}-3-isobutyl-succinic acid 4-benzyl ester 1-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R)-2-{3-[((S)-5-Benzyloxycarbonylamino-5-methoxycarbonyl-pentyl)-methyl-carbamoyloxy]-propyl}-3-isobutyl-succinic acid 4-benzyl ester 1-tert-butyl ester

There total 7 articles about (2S,3R)-2-{3-[((S)-5-Benzyloxycarbonylamino-5-methoxycarbonyl-pentyl)-methyl-carbamoyloxy]-propyl}-3-isobutyl-succinic acid 4-benzyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 359821-15-1
methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-6-(methylamino)hexanoate

: 191407-51-9
1-benzyl 4-tert-butyl (2R,3S)-2-isobutyl-3-(3-{[(4-nitrophenoxy)carbonyl]oxy}propyl)butanedioate

: 191407-52-0
(2S,3R)-2-{3-[((S)-5-Benzyloxycarbonylamino-5-methoxycarbonyl-pentyl)-methyl-carbamoyloxy]-propyl}-3-isobutyl-succinic acid 4-benzyl ester 1-tert-butyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 2h;
DOI:10.1021/jm010127e

Reference yield:

: 100-39-0
benzyl bromide

: 191407-52-0
(2S,3R)-2-{3-[((S)-5-Benzyloxycarbonylamino-5-methoxycarbonyl-pentyl)-methyl-carbamoyloxy]-propyl}-3-isobutyl-succinic acid 4-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 62 percent / DBU / benzene / 4 h / Heating

2.1: 9-BBN / tetrahydrofuran / 12 h / 20 °C

2.2: 64 percent / aq. H₂O₂; AcONa / tetrahydrofuran / 0.33 h / 0 °C

3.1: 91 percent / NMM / CH₂Cl₂ / 20 °C

4.1: K₂CO₃ / dimethylformamide / 2 h / 50 °C

With 4-methyl-morpholine; 9-borabicyclo[3.3.1]nonane dimer; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm010127e

Reference yield:

: 191406-75-4
4-benzyl 1-tert-butyl (2S,3R)-2-(3-hydroxypropyl)-3-isobutylbutanedioate

: 191407-52-0
(2S,3R)-2-{3-[((S)-5-Benzyloxycarbonylamino-5-methoxycarbonyl-pentyl)-methyl-carbamoyloxy]-propyl}-3-isobutyl-succinic acid 4-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / NMM / CH₂Cl₂ / 20 °C

2: K₂CO₃ / dimethylformamide / 2 h / 50 °C

With 4-methyl-morpholine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010127e