Technology Process of ((2R,3S,4S,5S,6S)-3,5-Dihydroxy-2-hydroxymethyl-6-methoxy-tetrahydro-pyran-4-yl)-carbamic acid benzyl ester
There total 1 articles about ((2R,3S,4S,5S,6S)-3,5-Dihydroxy-2-hydroxymethyl-6-methoxy-tetrahydro-pyran-4-yl)-carbamic acid benzyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate;
In
ethanol; water;
for 2h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 12 steps
1: pyridine / 36 h / Ambient temperature
2: H2 / 10percent Pd/C / ethanol / 18 h / 3192 Torr
3: CH3COONa / ethanol / 8 h / Heating
4: NaHCO3 / ethanol; H2O / 2 h / ice-cooling
5: 52 percent / aq. 0.4 M HCl / 16 h / 95 - 100 °C
6: 74 percent / conc. HCl / 0.25 h
7: 73 percent / pyridine
8: 96 percent / HgCl2, CdCO3 / H2O; acetone / 1 h / Heating
9: 86 percent / acetonitrile / 0.25 h / Heating
10: 25 percent / H2 / 10percent Pd/C / ethanol; acetic acid / 2 h / 3192 Torr / 2
11: 94 percent / BH3*Me2S / tetrahydrofuran / 4 °C / overnight
12: MeONa / methanol / 3 h
With
hydrogenchloride; cadmium(II) carbonate; dimethylsulfide borane complex; hydrogen; sodium methylate; sodium acetate; sodium hydrogencarbonate; mercury dichloride;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine; methanol; ethanol; water; acetic acid; acetone; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: pyridine / 36 h / Ambient temperature
2: H2 / 10percent Pd/C / ethanol / 18 h / 3192 Torr
3: CH3COONa / ethanol / 8 h / Heating
4: NaHCO3 / ethanol; H2O / 2 h / ice-cooling
5: 52 percent / aq. 0.4 M HCl / 16 h / 95 - 100 °C
6: 80 percent / BF3*Et2O / CHCl3 / 0.03 h / Ambient temperature; conc. HCl, 15 min
7: p-TsOH / 0.33 h / Heating
With
hydrogenchloride; boron trifluoride diethyl etherate; hydrogen; sodium acetate; sodium hydrogencarbonate; toluene-4-sulfonic acid;
palladium on activated charcoal;
In
pyridine; ethanol; chloroform; water;
