(R)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoic acid hydrochloride

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Chemical Name:(R)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoic acid hydrochloride
CAS No.:1431772-72-3
Molecular Formula:C₂₃H₂₂N₆O₂*ClH
Molecular Weight:450.928
Hs Code.:

Synonyms:(R)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoic acid hydrochloride

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Chemical Property of (R)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoic acid hydrochloride

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Technology Process of (R)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoic acid hydrochloride

There total 9 articles about (R)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431837-96-5
(R)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoic acid

: 1431772-72-3
(R)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoic acid hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; water; for 0.0833333h;

Reference yield:

: 1597-32-6
6-fluoro-pyridin-2-ylamine

: 1431772-72-3
(R)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: water / 0.5 h / 205 °C / Microwave irradiation

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / water; 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

3: sodium hydroxide / water / 4 h / 40 °C

4: hydrogenchloride / methanol; water / 0.08 h

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; In 1,4-dioxane; methanol; water;

Reference yield:

: 1431773-69-1
methyl 3-(6-aminopyridazin-3-yl)benzoate

: 1431772-72-3
(R)-3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: bromine; sodium hydrogencarbonate / methanol / 16.5 h / 20 °C

2: toluene-4-sulfonic acid / isopropyl alcohol / 40 h / 80 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / water; 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

4: sodium hydroxide / water / 4 h / 40 °C

5: hydrogenchloride / methanol; water / 0.08 h

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bromine; sodium hydrogencarbonate; caesium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; In 1,4-dioxane; methanol; water; isopropyl alcohol;