1-(4-(5-chloro-2-(phenylthio)phenyl)but-3-ynyl)-4-methylpiperazine

Base Information

• Chemical Name: 1-(4-(5-chloro-2-(phenylthio)phenyl)but-3-ynyl)-4-methylpiperazine
• CAS No.: 1100794-09-9
• Molecular Formula: C₂₁H₂₃ClN₂S
• Molecular Weight: 370.946
• Mol file: 1100794-09-9.mol

Synonyms:1-(4-(5-chloro-2-(phenylthio)phenyl)but-3-ynyl)-4-methylpiperazine

Chemical Property of 1-(4-(5-chloro-2-(phenylthio)phenyl)but-3-ynyl)-4-methylpiperazine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-(4-(5-chloro-2-(phenylthio)phenyl)but-3-ynyl)-4-methylpiperazine

There total 1 articles about 1-(4-(5-chloro-2-(phenylthio)phenyl)but-3-ynyl)-4-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

(4-chloro-2-iodophenyl)(phenyl)sulfane (1100794-07-7) + 3-(N-methylpiperazino)-prop-1-yne (388121-83-3) → 1-(4-(5-chloro-2-(phenylthio)phenyl)but-3-ynyl)-4-methylpiperazine (1100794-09-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 60 ℃; for 24h; Inert atmosphere;

DOI:10.1039/b806371k

Reference yield: 94.0%

1-(4-(5-chloro-2-(phenylthio)phenyl)but-3-ynyl)-4-methylpiperazine (1100794-09-9) → 1-(4-(5-chloro-2-(phenylthio)phenyl)butyl)-4-methylpiperazine (1100794-13-5)

Guidance literature:

With palladium hydroxide on carbon; hydrogen; In methanol; at 60 ℃; for 96h; Inert atmosphere;

DOI:10.1039/b806371k

upstream raw materials:

(4-chloro-2-iodophenyl)(phenyl)sulfane

3-(N-methylpiperazino)-prop-1-yne

Downstream raw materials:

1-(4-(5-chloro-2-(phenylthio)phenyl)butyl)-4-methylpiperazine