1-(3-Butynyl)-4-methyl-piperazine

Base Information

Chemical Name:1-(3-Butynyl)-4-methyl-piperazine
CAS No.:388121-83-3
Molecular Formula:C9H16 N2
Molecular Weight:152.239
Hs Code.:
European Community (EC) Number:839-868-8
Nikkaji Number:J2.671.402H
Mol file:388121-83-3.mol

Synonyms:388121-83-3;1-(3-BUTYNYL)-4-METHYL-PIPERAZINE;1-BUT-3-YNYL-4-METHYLPIPERAZINE;1-(BUT-3-YN-1-YL)-4-METHYLPIPERAZINE;Piperazine, 1-(3-butynyl)-4-methyl- (9CI);1-but-3-ynyl-4-methyl-piperazine;SCHEMBL312073;GZBWIJDICIGGKJ-UHFFFAOYSA-N;1-(but-3-ynyl)-4-methylpiperazine;AKOS010954413;AB73208;AT29256;Piperazine,1-(3-butynyl)-4-methyl-(9ci);CS-0225414;EN300-1238073;F2147-2120

Suppliers and Price of 1-(3-Butynyl)-4-methyl-piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Anichem
1-but-3-ynyl-4-methylpiperazine >95%
1g
$ 450.00

AK Scientific
1-(3-Butynyl)-4-methyl-piperazine
2.5g
$ 1459.00

AK Scientific
1-(3-Butynyl)-4-methyl-piperazine
250mg
$ 378.00

Total 3 raw suppliers

Chemical Property of 1-(3-Butynyl)-4-methyl-piperazine

Chemical Property:

PSA：6.48000
LogP:0.13290
XLogP3:0.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:152.131348519
Heavy Atom Count:11
Complexity:148

Purity/Quality:

98%min ^*data from raw suppliers

1-but-3-ynyl-4-methylpiperazine >95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCN(CC1)CCC#C
Uses 1-But-3-ynyl-4-methylpiperazine is used as a reactant in the preparation of alkynoylamino (arylamino)quinazolines or (arylamino)pyridopyrimidines and their activities as irreversible inhibitors of erbB tyrosine kinases such as erbB1, erbB2, and erbB4.

Technology Process of 1-(3-Butynyl)-4-methyl-piperazine

There total 2 articles about 1-(3-Butynyl)-4-methyl-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 109-01-3
1-methyl-piperazine

: 23418-85-1
3-butyn-1-yl p-toluenesulfonate

: 388121-83-3
3-(N-methylpiperazino)-prop-1-yne

Guidance literature:: With sodium carbonate; In N,N-dimethyl-formamide; at 20 - 80 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.ejmech.2009.04.049

Reference yield:

: 109-01-3
1-methyl-piperazine

: 23418-85-1
3-butyn-1-yl p-toluenesulfonate

: 1-(but-3-ynyl)-4-methylpiperazine tosylate

: 388121-83-3
3-(N-methylpiperazino)-prop-1-yne

Guidance literature:: at 80 ℃; for 4.5h;

Reference yield: 88.0%

: 364793-73-7
3-cyano-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxyquinolin-7-yl trifluoromethanesulfonate

: 388121-83-3
3-(N-methylpiperazino)-prop-1-yne

: 885482-95-1
4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[4-(4-methylpiperazin-1-yl)but-1-ynyl]-3-quinolinecarbonitrile

Guidance literature:: With potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine; In tetrahydrofuran; methanol; at 60 ℃; for 4h; Product distribution / selectivity;