dibenzyl({2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine

Base Information

Chemical Name:dibenzyl({2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine
CAS No.:1401029-10-4
Molecular Formula:C₃₁H₃₆FNO
Molecular Weight:457.631
Hs Code.:

Synonyms:dibenzyl({2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine

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Chemical Property of dibenzyl({2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine

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Technology Process of dibenzyl({2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine

There total 6 articles about dibenzyl({2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1401031-20-6
2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]acetonitrile

: 100-52-7
benzaldehyde

: 1401029-10-4
dibenzyl({2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine

Guidance literature:: With sodium sulfate; In dichloromethane; at 20 ℃;

Reference yield:

: 855398-57-1
6-oxa-spiro[4.5]decan-9-one

: 1401029-10-4
dibenzyl({2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; ammonium acetate / benzene / 2 h / Dean-Stark; Reflux

2: copper(l) iodide / diethyl ether / 1.5 h / 20 °C / Cooling with ice

3: potassium hydroxide / ethylene glycol / 3 h / 120 °C

4: AD-3 column / methanol / Supercritical conditions; Resolution of racemate

5: sodium sulfate / dichloromethane / 20 °C

With copper(l) iodide; ammonium acetate; acetic acid; sodium sulfate; potassium hydroxide; In methanol; diethyl ether; dichloromethane; ethylene glycol; benzene;

Reference yield:

: 1401031-14-8
methyl 2-cyano-2-[(9Z)-6-oxaspiro[4.5]decan-9-ylidene]acetate

: 1401029-10-4
dibenzyl({2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide / diethyl ether / 1.5 h / 20 °C / Cooling with ice

2: potassium hydroxide / ethylene glycol / 3 h / 120 °C

3: AD-3 column / methanol / Supercritical conditions; Resolution of racemate

4: sodium sulfate / dichloromethane / 20 °C

With copper(l) iodide; sodium sulfate; potassium hydroxide; In methanol; diethyl ether; dichloromethane; ethylene glycol;