(R)-2-(tert-Butyldiphenylsilyloxy)-3-(chloromethylthio)propanal diethyl acetal

Base Information

• Chemical Name: (R)-2-(tert-Butyldiphenylsilyloxy)-3-(chloromethylthio)propanal diethyl acetal
• CAS No.: 162893-10-9
• Molecular Formula: C₂₄H₃₅ClO₃SSi
• Molecular Weight: 467.145
• Mol file: 162893-10-9.mol

Synonyms:(R)-2-(tert-Butyldiphenylsilyloxy)-3-(chloromethylthio)propanal diethyl acetal

Chemical Property of (R)-2-(tert-Butyldiphenylsilyloxy)-3-(chloromethylthio)propanal diethyl acetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-(tert-Butyldiphenylsilyloxy)-3-(chloromethylthio)propanal diethyl acetal

There total 4 articles about (R)-2-(tert-Butyldiphenylsilyloxy)-3-(chloromethylthio)propanal diethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

chlorobromomethane (74-97-5) + (R)-2-(tert-Butyl-diphenyl-silanyloxy)-3,3-diethoxy-propane-1-thiol → (R)-2-(tert-Butyldiphenylsilyloxy)-3-(chloromethylthio)propanal diethyl acetal (162893-10-9)

Guidance literature:

With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride;

DOI:10.1002/recl.19951140107

Reference yield:

(S)-2-Hydroxy-3-(p-tolylsulfonyloxy)propanal diethyl acetal (162893-08-5) → (R)-2-(tert-Butyldiphenylsilyloxy)-3-(chloromethylthio)propanal diethyl acetal (162893-10-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 94 percent / imidazole / dimethylformamide / Ambient temperature

2: 70 percent / dimethylformamide

3: 70 percent / NaOMe / methanol

4: 97 percent / KOH / Et₃BnNCl

With 1H-imidazole; potassium hydroxide; sodium methylate; N-benzyl-N,N,N-triethylammonium chloride; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/recl.19951140107

Reference yield:

Thioacetic acid S-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-3,3-diethoxy-propyl] ester (162893-22-3) → (R)-2-(tert-Butyldiphenylsilyloxy)-3-(chloromethylthio)propanal diethyl acetal (162893-10-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / NaOMe / methanol

2: 97 percent / KOH / Et₃BnNCl

With potassium hydroxide; sodium methylate; N-benzyl-N,N,N-triethylammonium chloride; In methanol;

DOI:10.1002/recl.19951140107

upstream raw materials:

chlorobromomethane

(S)-2-Hydroxy-3-(p-tolylsulfonyloxy)propanal diethyl acetal

Thioacetic acid S-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-3,3-diethoxy-propyl] ester

(S)-2-(tert-Butyldiphenylsilyl)-3-(p-tolylsulfonyloxy)propanal diethyl acetal

Downstream raw materials:

(S)-2-(tert-Butyldiphenylsilyloxy)-3-<<2-(1H-indol-3-yl)ethyl>aminooxy>methylthiol-propanal diethyl acetal

C₃₈H₅₀N₂O₆SSi