(3R,3‘S,4’S)-tert-butyl 3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4'-hydroxy-2-oxo-[1,3'-bipiperidine]-1'-carboxylate

Base Information

Chemical Name:(3R,3‘S,4’S)-tert-butyl 3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4'-hydroxy-2-oxo-[1,3'-bipiperidine]-1'-carboxylate
CAS No.:1510832-31-1
Molecular Formula:C₂₂H₂₉ClF₃N₃O₄
Molecular Weight:491.938
Hs Code.:

Synonyms:(3R,3‘S,4’S)-tert-butyl 3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4'-hydroxy-2-oxo-[1,3'-bipiperidine]-1'-carboxylate

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Chemical Property of (3R,3‘S,4’S)-tert-butyl 3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4'-hydroxy-2-oxo-[1,3'-bipiperidine]-1'-carboxylate

Chemical Property:

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Technology Process of (3R,3‘S,4’S)-tert-butyl 3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4'-hydroxy-2-oxo-[1,3'-bipiperidine]-1'-carboxylate

There total 12 articles about (3R,3‘S,4’S)-tert-butyl 3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4'-hydroxy-2-oxo-[1,3'-bipiperidine]-1'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68766-96-1
ethyl (R)-2-pyrrolidone-5-carboxylate

: 1510832-31-1
(3R,3‘S,4’S)-tert-butyl 3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4'-hydroxy-2-oxo-[1,3'-bipiperidine]-1'-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 40 °C / Inert atmosphere

2: diisobutylaluminium hydride / 2-methyltetrahydrofuran; n-heptane / -45 - -35 °C / Inert atmosphere

3: sodium tris(acetoxy)borohydride / dimethyl sulfoxide / 2 h / 45 - 55 °C / Inert atmosphere

4: ethanol / dimethyl sulfoxide

With copper(l) iodide; ethanol; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; caesium carbonate; N,N`-dimethylethylenediamine; In 2-methyltetrahydrofuran; 1,4-dioxane; n-heptane; dimethyl sulfoxide;

Reference yield:

: 1510832-47-9
C₂₄H₃₅ClF₃N₃O₅

: 1510832-31-1
(3R,3‘S,4’S)-tert-butyl 3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4'-hydroxy-2-oxo-[1,3'-bipiperidine]-1'-carboxylate

Guidance literature:: With ethanol; In dimethyl sulfoxide;

Reference yield:

: 1510866-72-4
(3S,4S)-3-aminopiperidin-4-ol

: 1510832-31-1
(3R,3‘S,4’S)-tert-butyl 3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4'-hydroxy-2-oxo-[1,3'-bipiperidine]-1'-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 12 h

2: triethylamine / tetrahydrofuran / 4 h / 20 °C

3: sodium tris(acetoxy)borohydride / dimethyl sulfoxide / 2 h / 45 - 55 °C / Inert atmosphere

4: ethanol / dimethyl sulfoxide

With ethanol; sodium tris(acetoxy)borohydride; triethylamine; In tetrahydrofuran; dimethyl sulfoxide;